2015
DOI: 10.1128/iai.02908-14
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Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

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Cited by 77 publications
(77 citation statements)
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References 91 publications
(146 reference statements)
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“…IL-33 has been studied in a variety of inflammatory conditions, including allergic asthma, colitis, rheumatoid arthritis and cardiovascular diseases (reviewed in (16)). Likewise, IL-33 has been investigated in a variety of viral (influenza, RSV), bacterial (sepsis, Gram-negative keratitis, Gram-positive skin infection) and fungal ( C. albicans peritonitis, fungal asthma) infection models (17). By and large, IL-33 mediates the induction of type 2/Th2 responses and suppression of Th1 and inflammatory responses.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…IL-33 has been studied in a variety of inflammatory conditions, including allergic asthma, colitis, rheumatoid arthritis and cardiovascular diseases (reviewed in (16)). Likewise, IL-33 has been investigated in a variety of viral (influenza, RSV), bacterial (sepsis, Gram-negative keratitis, Gram-positive skin infection) and fungal ( C. albicans peritonitis, fungal asthma) infection models (17). By and large, IL-33 mediates the induction of type 2/Th2 responses and suppression of Th1 and inflammatory responses.…”
Section: Introductionmentioning
confidence: 99%
“…By and large, IL-33 mediates the induction of type 2/Th2 responses and suppression of Th1 and inflammatory responses. However, IL-33 has the potential to mediate a diverse array of functions, such as neutrophil recruitment and ROS/RNI induction, depending on the site and type of insult (17). Although IL-33 has yet to be investigated in IA, blockade of IL-33R signaling has been shown to improve fungal asthma severity, putatively through the modulation of pro-allergic responses (18).…”
Section: Introductionmentioning
confidence: 99%
“…IFN-γ potently inhibits IL-33-mediated ILC2 activation in vitro and in vivo following Listeria infection (Molofsky et al, 2015). IL-33 has been implicated in protection or pathology in a variety of additional bacterial and parasitic infections, as recently reviewed, (Rostan et al, 2015), although the mechanisms of action in these models are not well defined.…”
Section: Il-33 In Type 2 Immune Responsesmentioning
confidence: 99%
“…The alarmin cytokine IL-33 is known to be released during cellular demise mostly from barrier epithelial and endothelial cells (6,31,38) and modulates the immune responses by acting on ST2-bearing immune cells in different pathologies/inflammatory conditions (25,35). In liver, the endothelial cells expressed IL-33 constitutively, and its expression was induced during acute and chronic hepatitis in humans and mice (4,27).…”
Section: Discussionmentioning
confidence: 99%