Crucial cytotoxic and antimicrobial activity changes driven by amount of doped silver in biocompatible carbon nitride nanosheets

Silver Nanoparticle-Embedded Carbon Nitride: Antifungal Activity on Candida albicans and Toxicity toward Animal Cells

“…The g-CN nanosheet was inactive against both resistant and susceptible bacterial strains to antibiotics, but an antimicrobial activity was found when silver ions were added to g-CN. Furthermore, addition of 1 and 5% silver ions gradually improved the antibacterial activity with the MIC ranges of 125–250 and 31.2–62.5 μg/mL, respectively. , A similar observation was made by Rodmuang et al when 0.5 and 1% silver ions were added on the ZnO/g-C 3 N 4 composite …”

“…So, the starting material of g-CN did not influence the antimicrobial activity, confirming that g-CN is inactive against pathogens, as reported by previous studies. 49,50 This statement is also applicable to urea-derived graphitic carbon nitride (u-g-C 3 N 4 ), where u-g-C 3 N 4 failed to demonstrate any impact on the inhibition of bacterial survival. 49 The g-CN nanosheet was inactive against both resistant and susceptible bacterial strains to antibiotics, but an antimicrobial activity was found when silver ions were added to g-CN.…”

“…A dosedependent relationship between the biological activity and the amount of silver ions added was clearly noted. 50 So far, two antibacterial mechanisms of the metal-substituted g-C 3 N 4 composite have been reported: the release of metal ions and the generation of reactive oxygen from the composite upon exposure with visible or UV light at a specific time point. 50,69 Similar to those investigations, the results obtained in our…”

Synthesis, Crystal Structure, and Antibacterial Properties of Silver-Functionalized Low-Dimensional Layered Zirconium Phosphonates

“…The performance of 2D materials can be improved, and new and unique properties may be expressed upon their exfoliation in single layers or packets of few layers due to the huge increase in the surface area and the number of easily accessible active sites . Moreover, “superlattice-like heterostructures” obtained by combining two different types of nanosheets can be synthesized. , The nanosheets interact via van der Waals forces and exhibit synergistic effects in their catalytic, chemical, and optical properties. − Exfoliated 2D materials, due to their large surface area, can immobilize and stabilize large amounts of metals with antibacterial activity, such as Zn, Ag, , and Cu, in the form of both cations and metal nanoparticles (NPs). These functionalized nanosheets can be used singly or in combination with other nanosheets (superlattice-like heterostructures) as components of hydrogels, scaffolds for skin, bone, and cartilage tissue repair …”

“… 2 , 3 The nanosheets interact via van der Waals forces and exhibit synergistic effects in their catalytic, chemical, and optical properties. 4 − 9 Exfoliated 2D materials, due to their large surface area, can immobilize and stabilize large amounts of metals with antibacterial activity, such as Zn, 10 Ag, 11 , 12 and Cu, 13 in the form of both cations and metal nanoparticles (NPs). These functionalized nanosheets can be used singly or in combination with other nanosheets (superlattice-like heterostructures) as components of hydrogels, scaffolds for skin, bone, and cartilage tissue repair.…”