2017
DOI: 10.1016/j.bbrc.2017.05.020
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Crucial role of ATP-bound Sse1 in Upf1-dependent degradation of the truncated product

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“…Notably, we also demonstrated that truncated SERPINB7 protein from the mutant r.796c>u transcripts is degraded by the 26S proteasome. In yeast, mRNAs harboring a faux 3 0 UTR stimulate Upf1-dependent proteasome-mediated degradation of the PTC products (Kuroha et al, 2009;Kuroha et al, 2013;Sugiyama et al, 2017). These findings collectively indicate that mRNA and protein stability might be regulated by the aberrantly long 3 0 UTR of mutant transcripts in humans.…”
Section: Discussionmentioning
confidence: 84%
“…Notably, we also demonstrated that truncated SERPINB7 protein from the mutant r.796c>u transcripts is degraded by the 26S proteasome. In yeast, mRNAs harboring a faux 3 0 UTR stimulate Upf1-dependent proteasome-mediated degradation of the PTC products (Kuroha et al, 2009;Kuroha et al, 2013;Sugiyama et al, 2017). These findings collectively indicate that mRNA and protein stability might be regulated by the aberrantly long 3 0 UTR of mutant transcripts in humans.…”
Section: Discussionmentioning
confidence: 84%