Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers

Abstract

In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogenesis models. The chemopreventive agents produced from the cruciferous vegetables were recurrently proven to affect carcinogenesis throughout the onset and developmental phases of cancer formation. Likewise, findings from clinical investigations and epidemiological research supported this statement. The anticancer activities of these functional foods bioactive compounds are closely related to their ability to upregulate p53 and its related target genes, e.g., p21. As the “guardian of the genome,” the p53 family (p53, p63, and p73) plays a pivotal role in preventing the cancer progression associated with DNA damage. This review discusses the functional foods bioactive compounds derived from several cruciferous vegetables and their use in altering the tumor-suppressive effect of p53 proteins. The association between the mutation of p53 and the incidence of gastrointestinal malignancies (gastric, small intestine, colon, liver, and pancreatic cancers) is also discussed. This review contains crucial information about the use of cruciferous vegetables in the treatment of gastrointestinal tract malignancies.

A Comparative Study on the Nutrients, Mineral Elements, and Antioxidant Compounds in Different Types of Cruciferous Vegetables

“…Most cruciferous vegetables can be eaten fresh or cooked; the leaves can be used as animal feed; and the seeds can be used to produce edible oils [1]. They are important components of a healthy diet, supplying a multitude of health-related micronutrients and phytochemicals [2,3]. Furthermore, with increasing attention being paid to healthier lifestyle choices, the consumption of cruciferous vegetables is increasing.…”

Development and Application of a Selective Analytical Method for Indole Metabolites in Urine: Dietary Exposure Biomarkers for Broccoli Consumption

“…The recoveries of the proposed method for the three indole metabolites ranged from 73. 4 reusability experiment (Figure S5). These findings indicated that PDESs-MIP/VGO was stable and reliable for continuous CPT-SPE cycles, highlighting the good reusability of the developed PDESs-MIP/VGO−CPT-SPE method.…”

“…1−3 Broccoli, an extensively studied anticancer cruciferous vegetable, has been linked to various cancers such as breast, rectal, and gastric cancers, primarily because of its unique bioactive ingredients (e.g., glucosinolates, Glu). 4,5 Glu with its different side-chain R groups can be categorized into aliphatic, aromatic, and indole types. 6,7 The hydrolysis of Glu by myrosinase results in various products, including isothiocyanates, thiocyanate, and indole-3-acetonitrile (I3A).…”

Benzyl isothiocyanate ameliorates cognitive function in mice of chronic temporal lobe epilepsy

“…Among these, benzyl isothiocyanate (BITC) is a natural component with remarkable properties. Numerous studies have demonstrated that BITC has a variety of beneficial effects, including anti-inflammatory, antioxidant, anti-cancer, and cytoprotective properties ( 13 – 15 ). BITC has been the subject of several studies due to its potential in modulating the levels of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and enhancing the cellular antioxidant defense mechanism ( 16 ).…”