Cruciferous vegetables consumption and the risk of ovarian cancer: a meta-analysis of observational studies

Han, Bo; Li, Xuepeng; Yu, Tao

doi:10.1186/1746-1596-9-7

Cited by 45 publications

(33 citation statements)

References 26 publications

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“…Our studies have demonstrated that purified sulforaphane is able to overcome the pronounced therapy resistance of PDA in vitro and in vivo [7,8], and similar results have been obtained in experimental models of prostate and breast cancer [8][9][10][11]. Epidemiological studies have suggested that the frequent intake of cruciferous vegetables might be inversely associated with the risk of developing pancreatic cancer [12][13][14][15][16], as well as cancer of the breast, kidney, bladder and prostate [17][18][19][20][21][22]. A Canadian study observed a significantly decreased risk of extra-prostatic manifestations of stage III and IV prostate cancer when men frequently consumed broccoli and cauliflower [17].…”

Section: Introductionsupporting

confidence: 80%

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Lozanovski¹,

Polychronidis²,

Groß

et al. 2019

Invest New Drugs

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Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with short survival and limited therapeutic options. Broccoli sulforaphane is a promising new treatment due to the results of recent epidemiological, experimental and patient studies. Upon approval from the ethics committee and registration at ClinicalTrials.gov, 40 patients with palliative chemotherapy were placed into a placebo and treatment group in an unblinded fashion. Fifteen capsules with pulverized broccoli sprouts containing 90 mg/508 μmol sulforaphane and 180 mg/411 μmol glucoraphanin or methylcellulose were administered daily for up to 1 year. Twenty-nine patients were included in the treatment group and 11 patients were in the placebo group; these patients were followed for up to 1 year. The patient characteristics, overall survival and feasibility were assessed. Compared to those of the placebo group, the mean death rate was lower in the treatment group during the first 6 months after intake (day 30: 0%/18%, day 90: 0%/25%, and day 180: 25%/43%), and Kaplan-Meier analysis revealed a higher survival rate. There was a high drop-out rate (72% in the treatment group and 55% in the placebo group) after 1 year. We concluded from the Karnofsky index that the broccoli sprouts did not impact patient's self-care and overall abilities severely. The intake of 15 capsules daily was difficult for some patients, and the broccoli sprouts sometimes increased digestive problems, nausea and emesis. We did not obtain statistically significant results (p = 0.291 for the endpoint at day 180), but the knowledge about the feasibility is the basis for the development of new sulforaphane drugs.

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Section: Introductionsupporting

confidence: 80%

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Lozanovski¹,

Polychronidis²,

Groß

et al. 2019

Invest New Drugs

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“…Tests on animals and in vitro tests drew attention to the degradation products of glucosinolates which suppress the division of cancer cells, and accelerate the controlled death of the cell with damaged DNA. Furthermore, the protective effect of the enzyme degradation products of glucosinolates is associated with the induction of detoxifying enzymes in the tissues of the gastrointestinal tract, particularly of glutathione transferase, levelling the active form of carcinogenic compounds [21,22,23].…”

Section: Discussionmentioning

confidence: 99%

Modifiable lifestyle factors and ovarian cancer incidence in women

Plagens-Rotman¹,

Chmaj-Wierzchowska²,

Pięta³

et al. 2018

Ann Agric Environ Med.

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Introduction. A correct diet plays an important role in the prevention of malignant tumours. The risk of the disease may be reduced by introducing a number of changes to the daily diet. The most important changes concern the amount of fat in the diet, dietary fibre, antioxidants in the food and the reduction of substances having a significant impact on the development of malignant tumours. Objective. The aim of the study is to analyse the role of selected modifiable lifestyle factors affecting the development of ovarian cancer. Materials and method. The study covered healthy women and women with diagnosed ovarian cancer. A total of 850 women aged between 21-84 were studied. The study included women visiting the Gynaecology and Obstetrics Hospital of the University of Medical Sciences in Poznan, Poland, between 2011-2013. Patients recognized with malignant ovarian cancer were qualified into the study based on the histopathological examination of the material obtained during surgery. Results.Respondents who consumed fruit and vegetables several times a week have the odds ratio OR = 0.29 level; 95% CI 0.04-2.01 (p =.2085), compared to women not consuming fruit and vegetables at all. Consumption of 100 g of French fries and potato chips several times a week, results in a 2-fold increase in ovarian cancer. The OR for this group of women amounts to 2.06; 95% CI 0.53-7.99 (p=.2966). Conclusions. A diet rich in fruit and vegetables, including bulb vegetables, and grain products containing whole grains, should be introduced. It is recommended that the consumption of popular fast foods be eliminated.

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“…Diet may be modifying the risk of ovarian cancer through effect on endogenous hormones, antioxidant activity or other anticarcinogenic mechanisms. There is however a unanimous finding of reduced incidence of ovarian cancer with higher intake of vegetables especially for epithelial ovarian cancer [106][107][108][109][110][111]. The average finding is a reduction of risk by about more than 50%.…”

Section: Diet and Ovarian Cancermentioning

confidence: 99%

Risk Factors for Ovarian Cancer

Zayyan¹

2020

Tumor Progression and Metastasis

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Ovarian cancers remain a perplexing group of diseases that continue to raise questions over their etiology and clinical behavior. They are the most fatal of gynecological cancers. Despite a global lifetime risk of only 1-2%, they contribute the highest mortality and the lowest 5-year (overall) survival rate of just 35%. The three broad histological groups: epithelial, sex cord-stromal and germ cell cancers have different biologic behavior and may constitute different clinical disease entities. Of the eight subtypes in the epithelial group, high-grade serous are universally the most common and have the worst prognosis. Globally making 65-85% of all ovarian cancers, most of the focus on risk factors has been directed on the epithelial group but the importance of other primary malignancies cannot be overemphasized as a step towards understanding their etiology and clinical behavior. The normal ovary has none of the epithelia that produce the range of epithelial ovarian cancers or there is an obvious premalignant stage, symptoms are very vague, screening and early diagnosis are difficult and indeed unrewarding. No specific etiology is known for any of the histologic groups. However, commonly mentioned risk factors like increasing age, genetics, nulliparity, prolonged infertility, use of fertility drugs, high animal fat, obesity, endometriosis, polycystic ovary syndrome, previous history of cancer, use of hormone replacement therapy, pelvic inflammatory disease and smoking may not apply to all the subtypes, while factors like increasing parity, breast feeding, use of oral contraceptive pills, hysterectomy, tubal ligation and use of antioxidants may differ in the degree of protection they provide. There may also be geographical and probably racial variations in the relevance of some of the risk factors. Thorough understanding of the predisposing and protective factors of the various histologic subtypes is an important step understanding the disease and therefore improving treatment outcome or providing effective prevention.

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Cruciferous vegetables consumption and the risk of ovarian cancer: a meta-analysis of observational studies

Cited by 45 publications

References 26 publications

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Modifiable lifestyle factors and ovarian cancer incidence in women

Risk Factors for Ovarian Cancer

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