Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men

Abstract

Purpose To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms and colorectal cancer (CRC) in a population of Chinese men. Methods Using incidence density sampling, CRC cases (N = 340) diagnosed prior to December 31, 2010 within the Shanghai Men’s Health Study were matched to non-cases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate (ITC) levels from spot urine samples. GSTM1 and GSTT1 were categorized as null (0 copies) versus non-null (1 or 2 copies). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between CV intake and GST gene variants with CRC and statistical interactions were evaluated. Results CRC risk was not associated with CV intake, whether measured by self-report or by urinary ITC, nor with GST gene variants. No statistical interactions were detected between CV intake and GST gene variants on the odds of CRC. Stratifying by timing of urine sample collection and excluding CRC cases diagnosed in the first two years did not materially alter the results. Conclusions This study provides no evidence supporting the involvement of CV intake in the development of CRC in Chinese men.

Role of Urinary Biomarkers in the Diagnosis of Adenoma and Colorectal Cancer: A Systematic Review and Meta-Analysis

“…There were 25 duplicates (figure 1); 214 papers were excluded because 28 were conference posters, 54 were reviews, 84 regarded other subjects, 30 were animal, in vitro or laboratory technique studies, and 18 evaluated blood/serum/plasma or other tissues. Examination of the remaining 50 papers in the second stage of the PRISMA flow chart led to the exclusion of 31studies for the following reasons: 5 were reviews 1,19,42-44, one assessed animals 45, 5 involved laboratory technique validation 21, 46-49, one was a molecular biology study 50, 4 were survival analysis studies 51-54, 7 assessed the impact of dietary habits 57-61, 5 did not examine urine 62-66, one reported aggregate data for CRC, gastric cancer and pancreatic cancer 67, and finally 2 did not match the inclusion criteria 68,69.…”

A novel strategy to block mitotic progression for targeted therapy

“…Moreover, Cdc20 upregulation was associated with aggressive tumor progression and poor prognosis in gastric cancer [5] and primary non-small cell lung cancer [8] . Surprisingly, an increased expression of Cdc20 was detected in metastatic liver tissue in patients with colorectal cancer [6] . In addition, overexpression of Cdc20 was measured with a high grade in bladder, cervical, colon, endometrial, gastric, liver, ovarian, prostate, and renal carcinomas [9] .…”

“…diseases or predispose normal cells to become malignant [2,3] . Results from TCGA (The Cancer Genome Atlas) and pathological analysis have revealed a strong connection between aberrant upregulation of Cdc20 and various types of cancers [5][6][7][8] . For instance, severe accumulation of Cdc20 was detected in breast cancer cells and colon cancer cells compared to normal epithelial cells and adjacent normal tissues in cancer patient specimens.…”

GSTM1 gene polymorphism and the risk of colorectal cancer in a Saudi Arabian population

“…It has been suggested that homozygotic deletion of the functional alleles of GSTM1 increases the risk of colorectal cancer, although many studies conducted in several populations have produced debatable outcomes. Several research groups have reported a remarkable incidence of the GSTM1 null genotype in patients with colorectal cancer (Saeed et al, 2013;Cai et al, 2014;Cong et al, 2014;Ma et al, 2014;Teng et al, 2014;Djansugurova et al, 2015), while others failed to validate this result (Hezova et al, 2012;Kassab et al, 2014;Vogtmann et al, 2014).…”