Crude ethanolic extracts of different parts of <i>Gallesia integrifolia</i> (Phytolaccaceae) for the control of <i>Rhipicephalus microplus</i>

Bortolucci, Wanessa de Campos; Oliveira, Hérika Line Marko de; Oliva, Leiluana Roque; Gonçalves, José Eduardo; Júnior, Ranulfo Piau; Colauto, Nelson Barros; Linde, Giani Andréa; Gazim, Zilda Cristiani

doi:10.1080/01647954.2020.1805003

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…Regarding the chemical composition of the crude extracts identified by UHPLC (Table 3), it was possible to verify the presence of amino acids, triterpene saponins, triterpene glycosides, organosulfur compounds, flavonoids, vitamins, and organic acids. However, the compounds identified by Bortolucci et al [13] in the crude extracts of G. integrifolia differ from those reported in this study, being alpha acids, fatty acids, fatty acid esters, oxygenated sesquiterpenes, oxygenated diterpenes, phytosterol, steroidal compounds, triterpenes, vitamin precursors, and other compounds. The difference in chemical composition is probably due to the tool used for chemical identification, since Bortolucci et al [13] identified the extracts by gas chromatography coupled to mass spectrometry (GC-MS), while, in this study, the extracts were evaluated by high-performance liquid chromatography coupled to mass spectrometry (UHPLC-MS).…”

Section: Chemical Composition Of Crude Extractscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…integrifolia differ from those reported in this study, being alpha acids, fatty acids, fatty acid esters, oxygenated sesquiterpenes, oxygenated diterpenes, phytosterol, steroidal compounds, triterpenes, vitamin precursors, and other compounds. The difference in chemical composition is probably due to the tool used for chemical identification, since Bortolucci et al [ 13 ] identified the extracts by gas chromatography coupled to mass spectrometry (GC–MS), while, in this study, the extracts were evaluated by high-performance liquid chromatography coupled to mass spectrometry (UHPLC–MS). Another factor that may explain the difference between the extracts is the phenological changes and changes in rainfall over the years, which were discussed in detail in the essential oil section.…”

Section: Resultsmentioning

confidence: 99%

“…Studies conducted with essential oils and extracts from this species indicate anti-inflammatory, antiproliferative and antitumor [ 10 ], antifungal [ 8 , 11 ], acaricidal and larvicidal potential against Rhipicephalus microplus [ 12 , 13 ], larvicidal against Aedes aegypt [ 14 ], antiviral [ 15 ], antimycobacterial [ 9 ], and antiulcer [ 16 ] properties.…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical analysis of crude extracts from flowers and fruits of G. integrifolia indicated high concentrations of vitamin C and organosulfur compounds, and in leaves, high concentrations of phytol, fatty acids, and fatty acid esters [ 10 ]. Oxygenated diterpenes were also found in flowers and leaves, as well as phytosterol and triterpenes in fruits [ 13 ]. Organosulfur in essential oils represents 90% of all leaf, flower, and fruit compounds.…”

Section: Introductionmentioning

confidence: 99%

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Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

et al. 2023

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Gallesia integrifolia, a notable species in the Atlantic Forest, has been traditionally employed in folk medicine for treating rheumatism, asthma, and worms. This study investigated the cellular antioxidant, antiproliferative, and anti-inflammatory activities of the essential oils (EOs) and crude extracts (CEs) from G. integrifolia flowers, fruits, and leaves. The chemical identification of EOs was performed by GC–MS and CEs by UHPLC–MS. Cellular antioxidant and anti-inflammatory activities were assessed through mouse macrophage cell culture. In addition, the antiproliferative potential was evaluated in gastric, colorectal, breast, and lung tumor cell lines and non-tumor VERO cells. EOs predominantly contained organosulfur compounds in flowers (96.29%), fruits (94.94%), and leaves (90.72%). We found the main compound is 2,2′-Disulfanediyldiethanethiol in the EOs of flowers (47.00%), leaves (41.82%), and fruits (44.39%). Phenolic compounds were identified in CEs. The EOs and CEs demonstrated potential against the tumor cell lines tested (GI50 between 51 and 230 µg/mL). The selectivity index values were greater than 1.0 (1.01 to 3.37), suggesting a relative safety profile. Moreover, the anti-inflammatory activity IC50 ranged from 36.00 to 268 µg/mL, and the cellular oxidation inhibition ranged from 69% to 82%. The results suggest that oils and extracts derived from G. integrifolia have potential for use in various industrial sectors.

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Section: Chemical Composition Of Crude Extractscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

et al. 2023

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Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism

Tavares¹,

Sousa²,

Gomes³

et al. 2022

Ticks and Tick-borne Diseases

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Controle de carrapato bovino (Rhipicephalus microplus) com óleo essencial de folhas de Psidium rufum DC

Branco¹,

Oliveira²,

Bortolucci

et al. 2020

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Objetivo: avaliar a atividade acaricida e larvicida do óleo essencial das folhas de Psidium rufum frente a fêmeas ingurgitadas e larvas de Rhipicephalus microplus. Metodologia: o óleo essencial das folhas frescas de P. rufum foi extraído por hidrodestilação (2h) e analisado por cromatografia em fase gasosa acoplada à espectrometria de massas (CG-EM). As atividades acaricida e larvicida foram realizadas pela técnica de imersão de adultos e imersão larval (Larval Paket Test) utilizando o óleo essencial nas concentrações de 300 a 0,001 mg/mL. Como controle positivo foi utilizado uma solução comercial (cipermetrina 15%; clorpirifós 25%; citronelal 1%) a 0,005%, e como controle negativo uma solução aquosa de polissorbato (80) a 2,0%. As concentrações letais (CL50 e CL99) foram determinadas pela análise de Probitos. Resultados: no óleo essencial, foram identificados 55 compostos, sendo a classe majoritária os sesquiterpenos hidrocarbonetos (70,07%), e como majoritários o 1,8-cineole (19,00%); seguido do α-longipinene (18,62%). Os resultados evidenciaram que o óleo essencial de P. rufum a 6.20 mg/mL foi efetivo para controlar 73% da eclodibilidade de ovos reduzindo a oviposição e o número de carrapatos adultos e larvas. A CL99 para as larvas foi 2,50 mg/mL, e para as fêmeas ingurgitadas CL99 de 513,57 mg/mL. Conclusão: o óleo essenciaL das folhas de P. rufum demonstrou potencial para controlar R. microplus no ciclo de vida que corresponde a fase larval, indicando tratar-se de uma planta promissora para o desenvolvimento e aplicação de produtos contra carrapatos bovinos.

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Crude ethanolic extracts of different parts of Gallesia integrifolia (Phytolaccaceae) for the control of Rhipicephalus microplus

Cited by 4 publications

References 41 publications

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism

Controle de carrapato bovino (Rhipicephalus microplus) com óleo essencial de folhas de Psidium rufum DC

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