Crude Incidence Rate of Malignancy after Kidney Transplantation

Kim, Hyo Sun; Seo, Young Min; Park, Ui Jun; Kim, Hyoung Tae; Cho, Won Hyun; Hwang, Eun‐Sun; Han, Sang-Jae; Park, Sung Bae; Kim, Hyun Cheol; Jang, Hyuk Soo; Joo, S.H

doi:10.4285/jkstn.2010.24.3.182

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Also viral-associated tumors and urogenital tumors seemed to take a large proportion of malignancy after kidney transplantation (14). Ro In the previous Korean study, the incidence of malignancy was distributed 1.2% to 4.3%, and this was increased during the follow-up periods (16). In our study, malignancies after kidney transplantation were developed in 52 of 748 patients (7.2%) and GI malignancy (stomach cancer) was the most common.…”

Section: Discussionsupporting

confidence: 50%

Incidence of Post-transplant Malignancy after Renal Transplantation: Single Center Analysis

Choi

Kwon

2014

Korean J Transplant

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Background: Immunosuppression after kidney transplantation is associated with increased risk of malignancy, which has become the second most common cause of death among kidney transplant recipients. In this review, we report the incidence of malignancies after kidney transplantation in a single center and evaluate the incidence, characteristics, relationship to immunosuppressive drugs and discuss what clinicians must consider during a follow-up of patients after kidney transplantation.Methods: Between May 1978 and September 2013, a total of 748 kidney transplant patients who were able to undergo a follow-up process through electronic medical records were enrolled in this retrospective cohort study to determine the potential incidence and types of malignancy that may occur after kidney transplantation and the associated impact on patients and graft survival.Results: Among 748 patients, 63 cases of malignancy appeared in 54 patients (7.2%). Gastrointestinal cancer (12 cases, 19%) and post-transplant lymphoproliferative disorder (12 cases, 19%) were the two most common types of malignancy. The second most common type of malignancy was urinary tract malignancy in 10 patients. Two different types of malignancy were diagnosed in nine patients during our follow-up. The overall graft survival in malignancy patients was better, which may mean that malignancy did not affect the overall graft loss.Conclusions: Clinicians should be aware of the incidence of malignancy in transplant patients and perform routine examinations for early detection of malignancy.

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Section: Discussionsupporting

confidence: 50%

Incidence of Post-transplant Malignancy after Renal Transplantation: Single Center Analysis

Choi

Kwon

2014

Korean J Transplant

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“…Another study in South Korea reported a 4.3% rate of malignant development during a 37-year follow-up after RT at a single center [ 20 ]. Kim et al also confirmed a 4.2% rate of malignancy after RT among 757 patients [ 21 ]. In a study by Choi et al, malignancies after RT were found in 7.2% of patients [ 13 ].…”

Section: Discussionmentioning

confidence: 93%

Cancer risk after renal transplantation in South Korea: a nationwide population-based study

Heo

Noh

et al. 2018

BMC Nephrol

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BackgroundThis study aimed to evaluate patterns of posttransplant malignancies among renal transplant recipients (RTRs) in South Korea using nationwide data.MethodsThe nationwide cohort assessed in this study included RTRs from January 1, 2010, to December 31, 2014. We analyzed cancer incidence during the time course after renal transplantation. Additionally, we calculated standardized incidence ratios (SIRs) to evaluate the risk of malignancies in RTRs.ResultsA total of 1343 RTRs (871 males and 472 females, mean age 48.5 ± 11.6 years) were assessed. Among them, 104 (7.7%) developed malignancies after transplantation, most commonly in the thyroid cancer (23.1%). The SIR for all cancers was 3.54; particularly, the SIRs for renal cancer, myeloma, and non-Hodgkin lymphoma were 16.31, 24.02, and 28.64, respectively. Females showed a higher risk of malignancy than males (SIRs: 4.04 for women and 3.26 for men). The median interval between transplantation and malignancy diagnosis was 27.2 months (range 12.3–54.8 months).ConclusionsRTRs in South Korea demonstrated a high risk of malignancy after transplantation compared with the general population. This indicates that close surveillance and routine screening for cancer in RTRs are needed.

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“…A single-center study conducted in South Korea reported a malignancy development risk of 4.3% in the 37year post-transplant follow-up 2 . Kim et al also reported the development rate of post-transplant malignancy at 4.2% in 757 patients 7 . In our study, 21 patients (2%) from both sexes developed cancer.…”

Section: Discussionmentioning

confidence: 96%

Retrospective analysis of patients who develop cancer after renal transplantation: A 12-year experience in a single center

DEMİR¹,

BARLAS²

2022

Cumhuriyet Medical Journal

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Crude Incidence Rate of Malignancy after Kidney Transplantation

Cited by 5 publications

References 11 publications

Incidence of Post-transplant Malignancy after Renal Transplantation: Single Center Analysis

Incidence of Post-transplant Malignancy after Renal Transplantation: Single Center Analysis

Cancer risk after renal transplantation in South Korea: a nationwide population-based study

Retrospective analysis of patients who develop cancer after renal transplantation: A 12-year experience in a single center

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