The Trans-Mexican Volcanic Belt (TMVB), located in central Mexico, is an area for which low to moderate seismic risk is considered. This is based on the limited instrumental data available, even though large historical earthquakes have damaged some urban centers in the past. However, site effects is an aspect that must be considered in estimating risk, because there are some instances of important amplifications that have been documented with serious effects. In this work, ambient noise and earthquake records from 90 seismic permanent and temporary stations are used to analyze site response in the TMVB. The results obtained show a heterogeneous range in the value of the fundamental frequency. When possible, a comparison was made of the results obtained from ambient noise and earthquake records. In almost all these comparisons, no significant differences were observed in terms of the fundamental frequency. However, there were some stations with a flat average HVSR ambient noise curve that contradicted earthquake data results, which showed peaks at some frequencies. Our results are a first step towards categorizing the different site responses in the TMVB but in order to provide finer details, it is necessary to improve the actual monitoring conditions.