Crusted scabies in a patient with pemphigus vulgaris after treatment with rituximab and corticosteroids

Letter in reply: Crusted scabies mimicking a lupus flare after rituximab and belimumab

“…Our case further suggests a possible connection between increased risk of scabies infection after rituximab infusion, in addition to Ashrafzadeh and Layegh's 1 observations. This consideration should include patients with SLE who are treated with similar B cell–suppressing regimens, notably belimumab.…”

“…To the Editor: We found the case report from August 2020 published in the journal by Ashrafzadeh and Layegh, 1 concerning the association of rituximab with crusted scabies, to be informative. We want to reinforce this link through a patient encounter where a scabies infestation mimicked a lupus flare in a patient after rituximab and belimumab exposure, resulting in diagnostic delay.…”

A Puzzling Crusted Scabies On The Nipple Of An Immunocompetent Woman

“…Crusted scabies rarely occurs in an immunocompetent patient and are usually associated with immunodeficiency conditions such as HIV, leukaemia, systemic lupus erythematous, neurological diseases, congenital, or iatrogenic immunodeficiency (e.g., secondary to rituximab or prolonged use of topical corticosteroids) [4,5]. Classic scabies has a characteristic rash distribution because of immune-mediated and skin abrasion (e.g., rubbing, scratching).…”

An Overview of Clinical Manifestations of Dermatological Disorders in Intensive Care Units: What Should Intensivists Be Aware of?

“…It is an autoimmune disease in which the body’s immune system incorrectly recognizes skin proteins as foreign and thus produces antibodies to attack the foreign protein [ 15 , 16 ]. Trigger factors include medications [ 17 ] such as antibiotics, calcium channel blockers, ACE inhibitors, NSAIDs, salicylates, and interleukins, vaccines such as influenza [ 18 , 19 ], swine flu [ 20 ], tetanus toxoid [ 21 ], and COVID-19 vaccines [ 22 , 23 , 24 ], viral infections such as herpes simplex [ 25 ], hepatitis B and C [ 26 , 27 , 28 ], bacterial infections such as Helicobacter pylori [ 29 ], parasitic infections such as Toxoplasma gondii [ 30 , 31 ], and following organ transplantation [ 32 , 33 ]. Physical factors such as trauma, surgical interventions, thermal or electric burns, ultraviolet exposure, radiotherapy, and photodynamic therapy can also cause PV [ 34 ].…”