Cryoablation versus Partial Nephrectomy for Clinical T1b Renal Tumors: A Matched Group Comparative Analysis

Peri‐operative and local control outcomes of robot‐assisted partial nephrectomy vs percutaneous cryoablation for renal masses: comparison after matching on radiological stage and renal score

“…This is in line with previously published studies. Caputo et al observed a higher total postoperative complication rate for patients who underwent PN compared with a CA group (13.42% vs 7.23%, respectively; P = 0.10). The Clavien–Dindo score was higher in the PN group than in the CA group.…”

“…Long et al observed that 5‐year radiological recurrence‐free survival favoured PN compared with ablative therapies (92% vs 74%; log‐rank P < 0.001). Caputo et al compared oncological outcomes in patients with cT1b disease after 1:1 matching for main oncological characteristics. The rate of local recurrence was significantly higher for CA compared with RAPN ( P = 0.019).…”

“…While matching is necessary to improve methodological bias, only a prospective randomized trial would definitively determine whether CA is able to treat small renal tumours as well as PN in terms of recurrence‐free survival. Moreover, although surgery might provide improved local control, most studies failed to demonstrate any difference in terms of specific survival .…”

Computed tomography-guided percutaneous cryoablation of T1b renal tumors: safety, functional and oncological outcomes

“…Few studies have compared surgery and TA for T1b RCC. Caputo et al [15] compared 161 surgeries and 31 thermoablations for T1b patients, among whom five patients experienced local recurrences after cryoablation (23%) and four after PN (3.2%). After 1:1 matching, cryoablation was inferior to PN for recurrence-free survival, but did not significantly differ in CSS and overall survival.…”

Society of Interventional Radiology Quality Improvement Standards on Percutaneous Ablation in Renal Cell Carcinoma

“…Radical nephrectomy is suggested as a curative therapy for patients with either central, potentially complex T1b, and/or T2 tumors (>7.0 cm). According to guidelines, image-guided tumor ablation (IGTA) is a minimally invasive, image-guided therapy for RCC that can be considered as a potentially curative option for selected patients with T1a tumors (7,8), although limited case series have begun to explore IGTA in patients with larger tumors (9)(10)(11)(12)(13)(14)(15)(16)(17). A variety of ablative technologies for treating RCCs exist, including radiofrequency (RF) ablation, cryoablation, microwave (MW) ablation, and irreversible electroporation (IRE), but there is no strong evidence to support 1 modality over another in RCC (18).…”