Aim:To compare the efficacy of wound infiltration with Bupivacaine or Bupivacaine with fentanyl for post operative analgesia.Background:The role of Bupivacaine and fentanyl mixture as wound infiltration for post operative analgesia is less explored in human subjects.Materials and Methods:This prospective, randomized included 60 ASA grade I, II, and III patients in the age group of 20-75 years of age. The patients were randomized into two groups of 30 patients each: Group A received wound infiltration with a solution containing 0.5% bupivacaine (2 mg/kg), while, Group B received infiltration with a solution containing fentanyl 25 μg added to 0.5% bupivacaine (2 mg/kg).Results:None of the patients in both groups had unbearable incisional pain but addition of fentanyl to 0.5% bupivacaine reduced analgesic consumption in the postoperative period (P<0.05).Conclusion:Addition of opioids to local anesthetics results in better postoperative analgesia and reduced opioid requirement post operatively.