Cryobiopsy in the diagnosis of idiopathic pulmonary hemosiderosis: a case report

Kania, Aleksander; Misiaszek, Magdalena; Vašáková, Martina; Szlubowski, Artur; Bugalho, António; Pankowski, Juliusz; Szołkowska, Małgorzata; Roden, Anja C.; Celejewska‐Wójcik, Natalia; Nadziakiewicz, Paweł; Gnass, Maciej; Sładek, Krzysztof

doi:10.21037/jtd.2019.07.17

Cited by 9 publications

(2 citation statements)

References 27 publications

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“…Transbronchial biopsies can be easily performed during bronchoscopy, but the samples are of small size. Transbronchial cryobiopsy provides larger and better-preserved samples with a higher risk of bleeding complications [ 63 , 98 ]. The surgical lung biopsy, either by thoracotomy or video-assisted thoracoscopic surgery (VATS), was performed in 68% of patients in the IPH and 45% of the LHS cohort.…”

Section: Reviewmentioning

confidence: 99%

Comparative Analysis of Adult Patients With Idiopathic Pulmonary Hemosiderosis and Lane-Hamilton Syndrome: A Systematic Review of the Literature in the Period 1971-2022

Saha¹,

Datar²,

Aiman³

et al. 2022

Cureus

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Idiopathic pulmonary hemosiderosis (IPH) causes diffuse alveolar hemorrhage (DAH) by a yet unknown mechanism. The coexistence of IPH and celiac disease (CD), also known as Lane-Hamilton syndrome (LHS), has been reported in both pediatric and adult patients. The objective of this study was to compare demographics, clinical and radiologic findings, treatment, and outcomes between adult patients with IPH and LHS. This is a systematic review of the literature. Multiple databases were searched using appropriate formulas to identify relevant articles. A total of 60 studies reporting 65 patients were included in the review. Forty-nine of these patients had IPH and 16 had LHS. The prevalence of anti-CD antibodies among tested patients was 13/22 (59%). The symptom onset and diagnosis of IPH occurred earlier in patients with LHS. The median delay in diagnosis was the same between the two groups (52 weeks). The classic triad was more likely to be present in patients with LHS. Only 20% of patients in the LHS cohort had any significant gastrointestinal (GI) symptoms at the time of IPH diagnosis. A gluten-free diet alone was effective in the majority of patients. Fewer patients in the LHS cohort received systemic corticosteroid than the IPH cohort. The recurrence and mortality in patients with LHS appear to be less than in the IPH cohort. The prevalence of CD is 25% in adult patients with IPH. Patients with LHS may have a milder course than patients without CD. Serologic testing for CD should be performed in all patients diagnosed with IPH.

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Section: Reviewmentioning

confidence: 99%

Comparative Analysis of Adult Patients With Idiopathic Pulmonary Hemosiderosis and Lane-Hamilton Syndrome: A Systematic Review of the Literature in the Period 1971-2022

Saha¹,

Datar²,

Aiman³

et al. 2022

Cureus

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“…Historically, SLB has been considered the definite means of obtaining adequate specimens, until the invention of the novel technique of cryobiopsy in 2009. [ 2 ] Several cryotherapeutic techniques are available, which work based on the Joule–Thomson effect, to freeze tissues to extremely low temperatures for destruction (cryoablation), adhesion (cryo-adhesion) or biopsy (cryobiopsy). [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Safety, utility and clinical efficacy of cryobiopsy of lung in paediatric population—A single centre experience

Chandra,

Srikanta,

Madhusudan

et al. 2023

Lung India

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Background: Surgical lung biopsy (SLB) or video-assisted thoracic surgery (VATS) has been the traditional gold standard modality for diagnosing paediatric interstitial lung diseases. Cryobiopsy of the lung has recently been shown to be a novel technique with very good sensitivity and specificity in the diagnosis of various interstitial lung disorders in adults. Although there are a few case reports of the same in children, pediatric cryo lung biopsies are rarely performed due to the lack of the necessary equipment and the lack of expertise. Methods: A retrospective single-centre study was conducted with twelve consecutive children with diffuse parenchymal lung disease diagnosed both clinically and on high-resolution computed tomography (HRCT) of the chest which were included in the study between October 2020 and September 2022 to measure the diagnostic yield and safety of the procedure. The site from where cryobiopsy was to be done was chosen after a multidisciplinary meeting with the paediatric radiologist. Results: Twelve children (eight males and four females) were included in the study who underwent a cryobiopsy in the duration of two years. The mean age of the cases involved was 8 years and 3 months. With the youngest and oldest being 12 days and 15 years, respectively, all children underwent cryobiopsy as mentioned above. Diagnostic yield was achieved in 92% of cases. Conclusion: Cryobiopsy is a valuable diagnostic tool in childhood interstitial lung diseases, which offers a less invasive option for obtaining lung tissue samples with a better yield which can aid in accurate diagnosis, a good safety profile and a shorter hospital stay. Our study emphasizes that in trained centres, TBCB is a safe, effective and less invasive way to obtain tissue diagnosis in children with ChILD.

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Idiopathic pulmonary hemosiderosis: a review of the treatments used during the past 30 years and future directions

Saha

Milman

2020

Clin Rheumatol

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Cryobiopsy in the diagnosis of idiopathic pulmonary hemosiderosis: a case report

Cited by 9 publications

References 27 publications

Comparative Analysis of Adult Patients With Idiopathic Pulmonary Hemosiderosis and Lane-Hamilton Syndrome: A Systematic Review of the Literature in the Period 1971-2022

Comparative Analysis of Adult Patients With Idiopathic Pulmonary Hemosiderosis and Lane-Hamilton Syndrome: A Systematic Review of the Literature in the Period 1971-2022

Safety, utility and clinical efficacy of cryobiopsy of lung in paediatric population—A single centre experience

Idiopathic pulmonary hemosiderosis: a review of the treatments used during the past 30 years and future directions

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