Cryoglobulinæmia in Alcoholic Cirrhosis

Griffiths, L. L.; Gilchrist, Leo

doi:10.1016/s0140-6736(53)92007-8

Cited by 31 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with previous reports [6,[13][14][15][16][17][18][19] the most frequent association found in our case series was with liver dis eases: cirrhosis and chronic active hepati tis; two thirds of the patients presented with a purpura-arthralgia syndrome, and the hepatic involvement, completely asymptomatic, was discovered because of abnormal liver function tests and liver bi opsy. This high prevalence of cryoglobu lins is not an unexpected finding consider ing the frequency of immune complexes in acute and chronic hepatic diseases [20].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Secondary and Essential Cryoglobulinemias

et al. 1983

View full text Add to dashboard Cite

The clinical and immunochemical classification of 166 patients with cryo-globulinemia are presented. 52% of the cryoglobulins were detected in patients hospitalized because of various causes. The most frequent association was with liver and lymphoproliferative diseases (in particular with Waldenström’s macroglobulinemia); two thirds of the patients with liver diseases presented with a purpura-arthralgia syndrome, and the hepatic involvement was only brought to evidence by subsequent laboratory investigation. The presence of cryoglobulins did not usually interfere with the clinical course of the basic condition. In 79 patients the cryoglobulinemia was considered idi-opathic. In order to study the natural course of the disease in the idiopathic cases, a group of 35 patients had been followed up for 8–17 years: 37% developed a membranous proliferative glomerulonephritis, and more than half died of renal insufficiency; in 11% cirrhosis was diagnosed after a period of 4–9 years; another 11% developed a lymphoproliferative disease; of the remaining 40%, 2 are still asymptomatic, and the others are affected by purpura-arthralgia syndrome.

show abstract