Cryoprecipitate Therapy in Haemophilia

Cd, Forbes; Hunter, Julie; Rd, Barr; Jf, Davidson; Dw, Short; Ga, McDonald; Gp, McNicol; Wallace, J. Sim; As, Douglas

doi:10.1177/003693306901400101

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…10,22−26 The American Association of Blood Banks (AABB) recommends that frozen cryoprecipitate should be thawed prior to use in a protective plastic overwrap in a water bath at 30−37°C. 27,28 Once thawed, cryoprecipitate can be stored at 20−24°C for up to 4-6 hours. [29][30][31][32] We typically pool thawed preparations from 5 donors before use, and use these units within 4 hours.…”

Section: Highlightsmentioning

confidence: 99%

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Use of Cryoprecipitate in Newborn Infants

Maheshwari¹,

Tyagi²,

Guaragni³

et al. 2023

Newborn

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Cryoprecipitate is a transfusion blood product derived from fresh-frozen plasma (FFP), comprised mainly of the insoluble precipitate that gravitates to the bottom of the container when plasma is thawed and refrozen. It is highly enriched in coagulation factors I (fibrinogen), VIII, and XIII; von Willebrand factor (vWF); and fibronectin. In this article, we have reviewed currently available information on the preparation, properties, and clinical importance of cryoprecipitate in treating critically ill neonates. We have searched extensively in the databases PubMed, Embase, and Scopus after short-listing keywords to describe the current relevance of cryoprecipitate.

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Section: Highlightsmentioning

confidence: 99%

“…44,45 The cryoprecipitate should be used immediately, ideally within 4 hours of its being thawed and received from the blood bank, and should never be refrozen. 27,[46][47][48] The shelf life of thawed cryoprecipitate is short due to the loss of clotting factor activity, particularly that of factor VIII.…”

Section: Highlightsmentioning

confidence: 99%

Use of Cryoprecipitate in Newborn Infants

Maheshwari¹,

Tyagi²,

Guaragni³

et al. 2023

Newborn

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“…When plasma was the only existing product, levels of FVIII as low as 5% of normal were considered effective [20]. After the advent of concentrates, different levels have been proposed depending on the type and severity of the bleed: 12–35% for major bleeding episodes [11,34]; 12–17% for minor bleeding events, [34] 40–50% for severe trauma and 30% for minor events [35] and 10–20% for spontaneous bleeding episodes [36]. Table 2 depicts some of the regimens described in the literature using low doses of FVIII or FIX between the years of 1967 and 1982.…”

Section: Historical Reviewmentioning

confidence: 99%

Treatment on demand –in vivodose finding studies

Escobar¹

2003

Haemophilia

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Since the discovery of replacement therapy the goal of treatment for haemophilia patients has always been the prevention of haemorrhagic episodes. However, the "ideal"" plasma level needed to prevent hemathrosis or treat haemorrhages is still unknown. It seems that the doses of treatment have been arrived at by trial and error based in the pharmacokinetics of the factors and the characteristics of the replacement product. This review provides some guidelines for the treatment of haemophilia, however the doses are not based in randomized trials.

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Rupture of the ureter due to crushing injury in a boy with severe haemophilia

Forbes

Craig

Prentice

et al. 1971

Journal of British Surgery

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HAEXOSTATIC MANAGEMENT.-PreOperatiVely, screening tests for the presence of AGH inhibitors were carried out as described by Bxr, Forbes, MflicoL and Douglas A haemophilic boy, aged 14 years, presented with rupture of the upper end of the ureter as a result of a successfully carried out under cover of cryoglobulin precipitate therapy. Renal function tests carried out at z months were normal, although the isotope renogram showed slight diminution of function on the injured side and an intravenous pyelogram showed some narrowing of the ureter at the site of the anastomosis. crushing injury. Primary ureteranastomosis was (1 969). CqoPreciPitate dosage Was calculated by the RUPTURE of the upper ureter as a result of blunt trauma is rare, presumably because of its protected position in the abdomen and its natural elasticity. T h e following is an account of a boy with severe haemophilia who sustained a rupture of the upper end of a ureter as a result of a crushing injury. CASE REPORTThe patient, aged 14 years, was a severely affected haemophiliac with an antihaemophilic globulin (AHG) level of o U. per 100 ml. He had a history of multiple admissions to the Regional Haemophilia Centre with spontaneous haemarthroses, haematuria, and haematomata. His general health had been good except for mild bronchial asthma as a child.On this occasion he was admitted to the centre after having been crushed by the crowd at Ibrox Football Park, Glasgow, a disaster in which 66 people died. He had the features of traumatic asphyxia: cyanosis of the face, bilateral subconjunctival haemorrhages, extensive abrasions of the back from the upper thorax to the buttocks, and large haematomata of the head, arms, and legs. His only complaint, however, was of slight pain in the left loin. His blood-pressure was normal and his pulse-rate was IZO per minute.In the next IZ hours his condition deteriorated and he developed severe pain in the left loin with the appearance of a large, tender mass and gross haematuria. His bloodpressure fell, the pulse-rate rose, and the haematocrit, which had been 46 per cent on admission, dropped to 29 per cent. An intravenous pyelogram (Fig. I) showed lateral displacement of the left kidney at its lower pole with leakage of the contrast medium into the retroperitoneal space ; the bladder was elevated symmetrically, suggesting that blood and urine had tracked into the pelvis. A radiograph of the chest showed fractures of the sixth to ninth ribs on the right side near their anterior ends. FIG. I.-Intravenous pyelogram showing extravasation of the contrast medium into the retroperitoneal space and symmetrical elevation of the bladder by a haematoma in the pelvis.method described by Prentice, Breckenridge, Forman, and Ramoff (1967), and was administeredtwice dailyfor the first 4 days. On average, 1000 U. of AHG were given at each infusion, I U. being the amount of AHG present in I ml. of normal plasma. Plasma levels of AHG were determined before and after each infusion (Fig. 2). Aminocaproic acid was also given in a dose o...

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Cryoprecipitate Therapy in Haemophilia

Cited by 9 publications

References 16 publications

Use of Cryoprecipitate in Newborn Infants

Use of Cryoprecipitate in Newborn Infants

Treatment on demand –in vivodose finding studies

Rupture of the ureter due to crushing injury in a boy with severe haemophilia

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