Cryopreservation of a mother's oocytes for possible future use by her daughter with Turner syndrome: case report

Gidoni, Y.; Takefman, Janet; Holzer, Hananel; Elizur, Shai E.; Son, Weon‐Young; Chian, Ri‐Cheng; Tan, Seang Lin

doi:10.1016/j.fertnstert.2008.05.050

Cited by 21 publications

(15 citation statements)

References 41 publications

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“…In particular, it was shown that normovulatory women with high antral follicle count ) and elevated antiMüllerian hormone (AMH) levels (Fadini et al, 2011), traits that are suggestive of a good ovarian reserve, can be treated through IVM with significant chances of success. In the last few years, IVM has been also emphasized as an additional opportunity for female germ cell preservation in women suffering from cancer (Gidoni et al, 2008). Novel radio-and chemotherapies can significantly improve the prognosis of these patients (Mertens et al, 2001), but unfortunately imply major effects on ovarian function, often leading to premature ovarian failure.…”

Section: Importance Of Ivm In Research Animal Breeding and Human Artmentioning

confidence: 99%

Human oocyte maturation in vitro

Coticchio¹,

Canto²,

Guglielmo³

et al. 2012

Int. J. Dev. Biol.

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Oocytes from medium-sized antral follicles have already completed their growth phase and, if released from the follicular environment and cultured in vitro, are able to resume the meiotic process and mature. However, in vitro maturation (IVM) does not entirely support all the nuclear and cytoplasmic changes that occur physiologically as an effect of the ovulatory stimulus. Regardless, oocyte IVM is widely applied for the breeding of agriculturally important species. In assisted reproduction technology, IVM has been proposed as an alternative treatment to circumvent the drawbacks of standard ovarian stimulation regimens. Initially introduced to eliminate the risks of ovarian hyperstimulation syndrome afflicting women presenting with polycystic ovaries, subsequently IVM has been suggested to represent an additional approach suitable also for normovulatory patients. So far, in children born from IVM cycles, no doubts of an increased incidence of congenital abnormalities have been raised. Many more births would be achieved if novel IVM systems, currently dominated by empiricism, could be conceived according to more physiological criteria. Recent findings shedding new light on the control of meiotic progression, the support of cumulus cells to the oocyte cellular reorganization occurring during maturation, and the modulation of the stimulus that promotes oocyte maturation downstream the mid-cycle gonadotropin signal are likely to provide crucial hints for the development of more efficient IVM systems.

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Section: Importance Of Ivm In Research Animal Breeding and Human Artmentioning

confidence: 99%

Human oocyte maturation in vitro

Coticchio¹,

Canto²,

Guglielmo³

et al. 2012

Int. J. Dev. Biol.

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“…Until now, vitrification has been adopted to cryopreserve embryos [3,4], oocytes [5][6][7][8][9] and ovarian tissue [10][11][12][13]. Kuwayama reported that vitrification, compared with slow cooling, resulted in high survival rates for all stages of embryo development [14].…”

Section: Introductionmentioning

confidence: 99%

Sucrose affecting successful transplantation of vitrified-thawed mouse ovarian tissues

Zhang

Yao

et al. 2009

J Assist Reprod Genet

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Purpose The aim of this experiment is to detect effects of varying levels of sucrose on vitrified ovarian tissues. Methods Ovarian tissues of mice were vitrified-thawed. Mice were randomly assigned to the fresh control group and experimental groups. According to different concentration of sucrose in vitrification solution, the experimental groups were randomly divided into Group I (0.2 M sucrose), Group II (0.4 M sucrose), Group III (0.8 M sucrose) and Group IV (1.6 M sucrose). Cytology was followed throughout the oophorectomy and transplantation period. Hormone levels and density of follicle were measured 1 month after transplantation. Results The number of days before the resumption of estrous cycles in control group was significantly smaller than those in all of experimental groups. The serum estradiol levels of mice and the follicular density of ovarian grafts in control group were significantly higher than those in all of experimental groups. In addition, the number of days before the resumption of estrous cycles in Group II and Group III were smaller than those in Group I and Group IV. The serum estradiol levels of mice and the follicular density of ovarian grafts in Group II and Group III were significantly higher than those in Group I and Group IV. However, no difference was observed in the number of days before the resumption of estrous cycles and the serum estradiol levels between Group II and Group III. A similar follicular density was also observed in Group II and Group III.Conclusion Sucrose concentration of 0.4 M or 0.8 M in cryoprotective media is suitable for vitrifying mouse ovarian tissues.

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“…Dr. Chian's study proposed a possible method of fertility preservation in these women: immature oocytes should be retrieved in an unstimulated menstrual cycle prior to starting chemotherapy, matured in vitro, and then vitrified (a specific form of cryogenesis, or freezing of embryos) [8]. IVF is often not as viable a choice because hormonal administration may stimulate tumor development [90]. This study had a remarkably high clinical pregnancy prevalence of 44.7%, comparable to standard IVF, and no adverse obstetrical or perinatal complications were identified.…”

Section: Choosing Ivmmentioning

confidence: 99%

“…Studies indicate a constant 30-50% decrease in probability of successful pregnancy for cancer survivors [16]. The ASRM revealed in 2014 that oocyte cryopreservation (and its use with other forms of ART) is no longer an investigational procedure in fertility preservation for cancer patients due to the recent surge in data on clinical outcomes [16,29,90,91]. When discussing fertility treatment options, it is important to consider not only the method and timing of the gonadotoxic therapies, but also the specific cancer's parameters, patient age, and partner status [92].…”

Section: Cryopreservation and Fertility Restorationmentioning

confidence: 99%

“…Vitrification involves a much faster cooling process and uses a more complex solution of cryoprotectants in order to better preserve the tissue samples in the cooling. While any challenges to the tissue's environment may negatively impact the sample's survival, it has been demonstrated that cleavage-stage embryos as well as blastocysts that do not sustain injury during the cryopreservation process, whether it be vitrification or slow cooling, can implant at the same rate as their fresh equivalents [58,77,90,95,96]. In one of the largest randomized controlled trials conducted regarding the matter, over 3000 fresh oocytes were compared to 3000 vitrified oocytes.…”

Section: Cryopreservation and Fertility Restorationmentioning

confidence: 99%

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Assessment of the Field of Assisted Reproductive Technology: Improvements and the Future of Human In Vitro Fertilization

Brown¹

2015

JFIV Reprod Med Genet

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In vitro fertilization (IVF), a form of assisted reproductive technology, has expanded since its introduction in the 1970's to enable patients with prolonged infertility and/or clinical complications to produce biological offspring. This review analyzes the topics of controversy surrounding IVF, weighing evidence concerning contemporary fertility techniques that aim to advance the field of IVF. A comparison of single embryo transfer to double embryo transfer, in the context of economic expenditure and the likelihood of multiple pregnancy, provides support for electing the former. An ethically controversial topic is preimplantation genetic screening, a technology with the potential to reduce the incidence of genetic abnormalities, thereby increasing rates of healthy pregnancies. Lastly, the integration of in vitro maturation (IVM) can allow for a more diverse patient population to benefit from IVF treatment, while simultaneously avoiding several of the associated disadvantages. The future of IVF rests on continued research, and the resulting widespread integration of increasingly effective methods.

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Cryopreservation of a mother's oocytes for possible future use by her daughter with Turner syndrome: case report

Cited by 21 publications

References 41 publications

Human oocyte maturation in vitro

Human oocyte maturation in vitro

Sucrose affecting successful transplantation of vitrified-thawed mouse ovarian tissues

Assessment of the Field of Assisted Reproductive Technology: Improvements and the Future of Human In Vitro Fertilization

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