2024
DOI: 10.1002/cpz1.70068
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Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices

Alessandra M. Lodrini,
Esmee J. Groeneveld,
Meindert Palmen
et al.

Abstract: Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the extracellular matrix while maintaining the cytoarchitecture and electrical phenotype of CMs over extended periods. Despite their advantages over other cardiac models, LMS have limitations, particularly their reliance on slice quality. The primary factor influencing the quality… Show more

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