Cryopreservation of<i>in vitro</i>matured oocytes in addition to ovarian tissue freezing for fertility preservation in paediatric female cancer patients before and after cancer therapy

Abir, Ronit; Ben‐Aharon, Irit; Garor, Roni; Yaniv, Isaac; Ash, Susan; Stemmer, Salomon M.; Ben-Haroush, Avi; Freud, Enrique; Kravarušić, Dragan; Sapir, Onit; Fisch, Benjamin

doi:10.1093/humrep/dew007

Cited by 115 publications

(87 citation statements)

References 62 publications

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“…Xiao and colleagues recently proposed a two-step follicle culture process thought to promote growth and hormone production and further support follicle and oocyte maturation [83]. Recent studies have proposed utilizing IVM in concert with other fertility preservation techniques such as ovarian tissue preservation [84]. Such an approach, utilizing vitrified intro- matured oocytes in pre-pubertal cancer patients avoids the risk of “reseeding” cancer.…”

Section: Experimental Fertility Preservation Methods For Femalesmentioning

confidence: 99%

New promising strategies in oncofertility

Hudson

Stanley

Nahata

et al. 2017

Expert Review of Quality of Life in Cancer Care

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Introduction Approximately 70,000 adolescent and young adults (AYA) are diagnosed with cancer each year. While advancements in treatment have led to improved prognosis and survival for patients, these same treatments can adversely affect AYA reproductive capacity. Localized treatments such as surgery and radiation therapy may affect fertility by removing or damaging reproductive organs, and systemic therapies such as chemotherapy can be toxic to gonads, (ovaries and testicles), thus affecting fertility and/or endocrine function. This can be traumatic for AYA with cancer as survivors often express desire to have genetic children and report feelings of regret or depression as a result of infertility caused by cancer treatments. Areas Covered Emerging technologies in the field of assisted reproductive technology offer new promise for preserving the reproductive capacity of AYA cancer patients prior to treatment as well as providing alternatives for survivors. The following review revisits contemporary approaches to fertility preservation as well newly developing technologies. Expert Commentary There are several advances in ART that hold promise for patients and survivors. However there are challenges that inhibit uptake including poor communication between providers and patients about risks and fertility preservation options; high costs; and lack of insurance coverage for fertility preservation services.

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Section: Experimental Fertility Preservation Methods For Femalesmentioning

confidence: 99%

New promising strategies in oncofertility

Hudson

Stanley

Nahata

et al. 2017

Expert Review of Quality of Life in Cancer Care

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“…In vitro maturation (IVM) involves the collection of immature oocytes from unstimulated ovaries or ovarian tissue followed by the maturation of oocytes in vitro . IVM allows for timely FP that does not require stimulatory cycles and will not result in the transfer of cancer cells .…”

Section: What Types Of Fp Are Available?mentioning

confidence: 99%

Oncofertility—An emerging discipline rather than a special consideration

Anazodo

Ataman

Jayasinghe

et al. 2018

Pediatric Blood & Cancer

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Originally absent from the oncologist's consult, then placed in a 'quality of life' rubric, oncofertility should now be an essential part of a comprehensive cancer treatment plan in patients of reproductive age, including adolescents and young adults (AYAs). Oncofertility encompasses the endocrine health of the patient, as well as fertility management options. Thus, pubertal transitions in males and females, bone health, and menstrual health are all part of this discipline, enabling practitioners to work in interdisciplinary teams to solve problems in reproductive health. This review provides a summary of the essential considerations required for the assessement of reproductive risk and choice of fertility preservation options as well as considerations for developing oncofertility services for AYAs.

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“…8 This is because the methods for oocyte cryopreservation are still suboptimal. 5, 9–13 A typical oocyte cryopreservation procedure includes addition/removal of cryoprotective agents (CPAs) and freeze-thaw cycles, which may put the cells at the risk of injuries caused by osmotic shock and extra-/intra-cellular ice formation. 14, 15 Quantitative understanding of cell responses upon such non-isotonic conditions and accurate measurement of the transport properties of the oocyte membrane are of considerable importance to the fields of oocyte cryopreservation.…”

Section: Introductionmentioning

confidence: 99%

A microfluidic perfusion approach for on-chip characterization of the transport properties of human oocytes

Zhao

Zhang

et al. 2017

Lab Chip

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Accurate characterization of the cell membrane transport properties of human oocytes is of great significance to reproductive pharmacology, fertility preservation, and assisted reproduction. However, the commonly used manual method for quantifying the transport properties is associated with uncontrolled operator-to-operator and run-to-run variability. Here, we report a novel sandwich structured microfluidic device that can be readily fabricated for characterizing oocyte membrane transport properties. Owing to its capacity of excellent control of both solution replacement and temperature in the microchannel, the temperature-dependent permeability of oocyte membrane can be precisely characterized. Furthermore, the fertilization and developmental competence analysis post perfusion indicate that our approach does not compromise the physiological function of in-vitro matured human oocytes. Collectively, we present the development of a novel sandwich structured microfluidic device based approach that allows for on-chip characterization of the transport properties of human oocytes under innocuous osmotic shock or injury to the cells.

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Cryopreservation ofin vitromatured oocytes in addition to ovarian tissue freezing for fertility preservation in paediatric female cancer patients before and after cancer therapy

Abstract: N/A.

Cited by 115 publications

References 62 publications

New promising strategies in oncofertility

New promising strategies in oncofertility

Oncofertility—An emerging discipline rather than a special consideration

A microfluidic perfusion approach for on-chip characterization of the transport properties of human oocytes

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