P lants have been of the utmost importance since antiquity for a variety of reasons. It is common knowledge that plants are a significant source of natural compounds that can be used to develop cutting-edge drugs that can protect humans against a range of harmful infections (Suntar et al., 2018;Ibrahim et al., 2020). Drinking fruit juice aids in the preservation of good health and the prevention of numerous diseases. Humans frequently consume citrus fruit juice because of its distinctive flavor and nutritional benefits. Juice's favorable health effects have been attributed in part to its abundance of vitamin C (ascorbic acid) (Ibrahim & Muhammad, 2016;Klimek-Szczykutowicz et al., 2020). Citrus fruits contain a wide range of bioactive substances, such as phenolics, flavonoids, vitamins, and essential oils. These bioactive substances have been used as anti-inflammatory, anticancer, anti-oxidative, and antibacterial effects (Ibrahim et al., 2015; Al-Ghareebawi et al., 2021). In addition, lemon juice has a high ascorbic acid and citric concentration, which gives its acidic behavior (Ekawati & Darmanto, 2019;Singh et al., 2020).Plants can produce nitrogen compounds (amines, alkaloids), terpenoids (as well as carotenoids), vitamins, and endogenous metabolites (Henderson, et.al. 2018) in addition to aromatic molecules including quinones, flavonoids, phenolic acids, coumarins, stilbenes, lignans, and