2000
DOI: 10.1016/s0194-59980070024-6
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Cryopreserved, Irradiated Tracheal Homograft Transplantation for Laryngotracheal Reconstruction in Human Beings

Abstract: Subglottic tracheal stenosis is a common clinical entity. Management in severe cases is often problematic. Various techniques for tracheal replacement have been used with varying degrees of success. In this study we used cryopreserved, irradiated tracheal homografts, the use of which in human beings has not been reported previously. In a sterile setup, the tracheas were harvested from donor cadavers within 24 hours of death. The grafts were initially kept at 57°C for 20 minutes; they were then placed in a −70°… Show more

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Cited by 8 publications
(16 citation statements)
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“…It is probably reasonable to believe that the remaining epithelium and subepithelial structures of the donor trachea might slough off shortly after transplantation. This may explain why there was no graft‐vs‐host reaction or graft rejection in the previous report by Kunachak et al 2 The postoperative macroscopic and microscopic appearance of normal tracheal mucosa most likely reflected migration of the recipient tracheal mucosa onto the de‐epithelialized framework of transplanted donor trachea. This hypothesis was supported by genomic difference between the mucosa of the tracheal graft pre‐ and postoperatively, and genomic compatibility between the recipient mucosa and regenerated mucosa at the transplanted site postoperatively.…”
Section: Discussionmentioning
confidence: 77%
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“…It is probably reasonable to believe that the remaining epithelium and subepithelial structures of the donor trachea might slough off shortly after transplantation. This may explain why there was no graft‐vs‐host reaction or graft rejection in the previous report by Kunachak et al 2 The postoperative macroscopic and microscopic appearance of normal tracheal mucosa most likely reflected migration of the recipient tracheal mucosa onto the de‐epithelialized framework of transplanted donor trachea. This hypothesis was supported by genomic difference between the mucosa of the tracheal graft pre‐ and postoperatively, and genomic compatibility between the recipient mucosa and regenerated mucosa at the transplanted site postoperatively.…”
Section: Discussionmentioning
confidence: 77%
“…Thirty samples from six sets of specimens, acquired from the tracheas of six donors and the corresponding recipients, each set consisting of five samples of tracheal mucosa, were studied. Sample 1 was taken from deep‐frozen irradiated donor tracheal homograft (described previously 2 ) just before transplantation; sample 2 was taken from the recipient area adjacent to the operating field; sample 3 came from the grafted site eight months postoperatively; and samples 4 and 5 were from the donor trachea and the transplanted site eight months postoperatively.…”
Section: Methodsmentioning
confidence: 99%
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