Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis

Wojtecka-Lukasik, E; Księżopolska-Orłowska, Krystyna; Gaszewska, Ewa; Krasowicz-Towalska, Olga; Rzodkiewicz, Przemysław; Maślińska, D.; Szukiewicz, Dariusz; Maśliński, S

doi:10.1007/s00011-009-0144-1

Cited by 27 publications

(11 citation statements)

References 3 publications

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“…Wojtecka-Lukasik et al confirm that the beneficial clinical effects of whole-body cryotherapy in patients with rheumatoid arthritis are in part due to the action on the processes of production, release, and the degradation of histamine [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Gizińska

Rutkowski

Romanowski³

et al. 2015

BioMed Research International

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Whole-body cryotherapy (WBC) has been frequently used to supplement the rehabilitation of patients with rheumatoid arthritis (RA). The aim of this study was to compare the effect of WBC and traditional rehabilitation (TR) on clinical parameters and systemic levels of IL-6, TNF-α in patients with RA. The study group comprised 25 patients who were subjected to WBC (−110°C) and 19 patients who underwent a traditional rehabilitation program. Some clinical variables and levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were used to assess the outcomes. After therapy both groups exhibited similar improvement in pain, disease activity, fatigue, time of walking, and the number of steps over a distance of 50 m. Only significantly better results were observed in HAQ in TR group (p < 0.05). However, similar significant reduction in IL-6 and TNF-α level was observed. The results showed positive effects of a 2-week rehabilitation program for patients with RA regardless of the kind of the applied physical procedure.

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Section: Discussionmentioning

confidence: 99%

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Gizińska

Rutkowski

Romanowski³

et al. 2015

BioMed Research International

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“…In healthy individuals the analgesic and relaxing effects persist for several months after a series of cryotherapy sessions (Zagrobelny and Zimmer, 1999; Wojtecka-Lukasik et al, 2010). In this study 10 cryogenic sessions were applied during 10 consecutive days as this is the most frequently applied procedure, recommended by the producers of cryogenic chambers, which does not mean it is optimal.…”

Section: Discussionmentioning

confidence: 99%

Impact of 10 Sessions of Whole Body Cryostimulation on Cutaneous Microcirculation Measured by Laser Doppler Flowmetry

Szyguła

Dybek

Klimek

et al. 2011

Journal of Human Kinetics

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The aim of the present study was to evaluate the basic and evoked blood flow in the skin microcirculation of the hand, one day and ten days after a series of 10 whole body cryostimulation sessions, in healthy individuals.The study group included 32 volunteers – 16 women and 16 men. The volunteers underwent 10 sessions of cryotherapy in a cryogenic chamber. The variables were recorded before the series of 10 whole body cryostimulation sessions (first measurement), one day after the last session (second measurement) and ten days later (third measurement). Rest flow, post-occlusive hyperaemic reaction, reaction to temperature and arterio–venous reflex index were evaluated by laser Doppler flowmetry.The values recorded for rest flow, a post-occlusive hyperaemic reaction, a reaction to temperature and arterio – venous reflex index were significantly higher both in the second and third measurement compared to the initial one. Differences were recorded both in men and women. The values of frequency in the range of 0,01 Hz to 2 Hz (heart frequency dependent) were significantly lower after whole-body cryostimulation in both men and women. In the range of myogenic frequency significantly higher values were recorded in the second and third measurement compared to the first one.Recorded data suggest improved response of the cutaneous microcirculation to applied stimuli in both women and men. Positive effects of cryostimulation persist in the tested group for 10 consecutive days.

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“…Moreover, a growing body of literature [ 10 , 16 ] examined the use of cryotherapy to relieve rheumatic and inflammatory diseases such as rheumatoid arthritis. Cryotherapy has been used as a rehabilitation treatment in patients suffering from inflammatory arthritis due its analgesic effect [ 12 , 18 ] and its efficient effects in reducing inflammatory mediator’s activity such as pro-inflammatory cytokines [ 6 ], histamine levels [ 35 ] and oxidative stress [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients

et al. 2020

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Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used proton nuclear magnetic resonance (1H NMR) spectroscopy to assess the metabolite patterns in synovial fluid (SF) in patients with knee arthritis (n = 46) before (D0) and after (D1, 24 h later) two applications of local cryotherapy. Spectra from aqueous samples and organic extracts were obtained with an 11.75 Tesla spectrometer. The metabolite concentrations within the SF were compared between D1 and D0 using multiple comparisons with the application of a false discovery rate (FDR) adjusted at 10% for each metabolite. A total of 32 metabolites/chemical structures were identified including amino acids, organic acids, fatty acids or sugars. Pyruvate, alanine, citrate, threonine was significantly higher at D1 vs D0 (p < 0.05). Tyrosine concentration significantly decreases after cryotherapy application (p < 0.001). We did not observe any effect of gender and cooling technique on metabolite concentrations between D0 and D1 (p > 0.05). The present study provides new insight into a short-term effect of cold stimulus in synovial fluid from patients with knee arthritis. Our observations suggest that the increased level of metabolites involved in energy metabolism may explain the underlying molecular pathways that mediate the antioxidant and anti-inflammatory capacities of cryotherapy.

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Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis

Abstract: It may be concluded that the beneficial clinical effects of cryotherapy in RA patients are in part due to the action on the production, release, or degradation of histamine.

Cited by 27 publications

References 3 publications

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Impact of 10 Sessions of Whole Body Cryostimulation on Cutaneous Microcirculation Measured by Laser Doppler Flowmetry

1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients

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