Cryotherapy for canker in a horse

Mishra, P. N.; Bose, V.S.C.; Rao, A. T.; Panda, Sasmita

doi:10.1136/vr.142.11.284

Cited by 9 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is important however not to debride too deeply at the frog apex to avoid penetrating deeper structures. Although not performed in this case, cryotherapy has been advocated following debridement in some cases (Mishra et al , 1998).…”

Section: Discussionmentioning

confidence: 99%

Case report: Surgical treatment of canker of a horse's foot

Milner¹,

Rowley-Neale²

2011

Companion Animal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Case report: Surgical treatment of canker of a horse's foot

Milner¹,

Rowley-Neale²

2011

Companion Animal

View full text Add to dashboard Cite

show abstract

“…Equiner Hufkrebs wird als Pododermatitis chronica verrucosa sive migrans bezeichnet 1 und meint die destruktive und progressive Pododermatitis mit Veränderungen im Verhornungsprozess der Keratinozyten (Para- und Hyperkeratose) 2 – 5 . Hufkrebs ist kein Tumor im klassischen Sinn, bei dem Tumorzellen wuchern, sondern ein chronischer Prozess 4 .…”

Section: Introductionunclassified

“…Pferde, die öfter Zugang zu sumpfigen und feuchten Gebieten haben, erkranken häufiger 1 . Der Hufkrebs kann einen oder mehrere Hufe betreffen, wobei eine mögliche Gliedmaßenprädisposition eher uneinheitlich diskutiert wird 2 – 4 , 12 , 15 – 18 . Esel, Maulesel und Maultiere sind kaum betroffen 1 .…”

Section: Introductionunclassified

Hufkrebs – Immer wieder aktuell

Sette¹,

Martens²

2023

pferde spiegel

View full text Add to dashboard Cite

show abstract

“…Equine hoof canker (Pododermatitis chronica verrucosa sive migrans) is described as destructive and progressive pododermatitis with alterations in the cornification process of the keratinocytes (parakeratosis and hyperkeratosis). 15,24,26 Extensive proliferation of the dermal papillary body with subsequent absence of epidermal cornification is reported to be a major feature of disease. 23,24 Hoof canker can affect one or more hooves, and compromises the use and welfare of horses due to ensuing instability of affected hoof capsules and lameness at late stages.…”

Section: Introductionmentioning

confidence: 99%

Equine Hoof Canker: Cell Proliferation and Morphology

et al. 2017

View full text Add to dashboard Cite

Hoof canker is described as progressive pododermatitis of the equine hoof with absent epidermal cornification and extensive proliferation of the dermal papillary body; however, in-depth research on the type of proliferative activity has not yet been reported. The aim of the present study was to determine cell-specific proliferation patterns together with morphological analysis of hoof canker tissue.Tissues removed during surgery from 19 horses presented for treatment of canker were compared to similar postmortem tissues of healthy hooves of 10 horses.Morphological alterations visible in light microscopy were assessed semiquantitatively and graded for severity. Proliferative activity was evaluated by means of anti-PCNA (proliferative cell nuclear antigen) and anti-Ki67 immunohistochemistry.Histologically, canker tissue showed five major morphological alterations, the presence of lacunae, vacuoles, giant cells, hemorrhage and inflammation, not seen in control tissue. Also, there was a notable koilocytotic appearance of keratinocytes in canker tissue. Immunohistochemistry revealed increased levels of PCNA protein expression in keratinocytes and fibroblasts of canker tissue compared to control tissue. In control tissue, keratinocytes showed higher levels of Ki67 compared to canker tissue, while the dermal fibroblasts of both groups showed similar levels of Ki67, indicating similar proliferative activity of less than 3% of total dermal fibroblasts.These results demonstrate that, in contrast to previous reports, there is no evidence for increased proliferative activity of the dermal papillary body associated with hoof canker. Increased levels of PCNA protein expression and morphological alterations indicate dysregulation of keratinocyte differentiation constitutes a key event in equine hoof canker development. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 3,9,19,20,28 However, for any of these, a causal association with the development of disease remains to be established. Morphological studies of hoof canker tissues are rare. 24, 26Ballooning of the keratinocytes, mainly in the Stratum germinativum of the frog, has been reported together with the occurrence of perinuclear vacuoles in the cells of deep layers of the Stratum spongiosum; the cells of the corium are covered by a thin layer of defective epidermis, leading to an increased risk of infection and bleeding. 26To our knowledge, the proliferative character of canker has not yet been analyzed in detail. Immunohistochemistry allows characterization of tissue proliferation, as has been shown in a number of potentially metaplastic or neoplastic tissues. 4,1...

show abstract

Cryotherapy for canker in a horse

Cited by 9 publications

References 2 publications

Case report: Surgical treatment of canker of a horse's foot

Case report: Surgical treatment of canker of a horse's foot

Hufkrebs – Immer wieder aktuell

Equine Hoof Canker: Cell Proliferation and Morphology

Contact Info

Product

Resources

About