Cryotherapy for the prevention of chemotherapy-induced peripheral neuropathy: A systematic review

Bailey, Andrea G; Brown, Jamie N.; Hammond, Julia M

doi:10.1177/1078155220959431

Cited by 27 publications

(24 citation statements)

References 27 publications

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“…Firstly, to our knowledge, this is the first meta-analysis to have quantitatively examined the effects of cryotherapy on the prevention of TIPN. Although Bailey et al.’s ( 35 ) study systematically reviewed the preventive effect of cryotherapy on TIPN and discussed the contradicting evidence, it was not analyzed further. Secondly, most of former meta-analyses about treatments of CIPN did not specify the chemotherapy regimens, which have different characteristics ( 13 , 36 , 37 ), while, in our study, only peripheral neuropathy induced by taxanes was analyzed and from which the results may be more reliable.…”

Section: Discussionmentioning

confidence: 99%

Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

et al. 2021

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PurposeTaxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clinical guidelines for the prevention of TIPN. Although there are a considerable number of studies which explored the use of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN), there is insufficient large-scale clinical evidence. We performed a meta-analysis on the current available evidence to examine whether cryotherapy can prevent TIPN in cancer patients receiving taxanes.MethodsWe searched databases including PubMed, Embase, and Cochrane from inception to August 3, 2021 for eligible trials. Clinical trials that examined the efficacy of cryotherapy for prevention of TIPN were included. The primary outcome was the incidence of TIPN, and secondary outcomes were incidence of taxane dose reduction and changes in nerve conduction studies. The meta-analysis software (RevMan 5.3) was used to analyze the data.ResultsWe analyzed 2250 patients from 9 trials. Assessments using the Common Terminology Criteria for Adverse Events (CTCAE) score showed that cryotherapy could significantly reduce the incidence of motor and sensory neuropathy of grade≥2 (sensory: RR 0.65, 95%CI 0.56 to 0.75, p<0.00001; motor: RR 0.18, 95% CI [0.03, 0.94], p=0.04). When evaluated using the Patient Neuropathy Questionnaire (PNQ), cryotherapy demonstrated significant reduction in the incidence of sensory neuropathy (RR 0.11, 95% CI 0.04 to 0.31], p<0.0001), but did not show significant reduction in the incidence of motor neuropathy (RR 0.46, 95% CI 0.11 to 1.88, p=0.28). Cryotherapy was associated with reduced incidences of taxane dose reduction due to TIPN (RR 0.48, 95% CI [0.24, 0.95], p=0.04) and had potential to preserve motor nerves.ConclusionsCryotherapy is likely to prevent TIPN in patients receiving taxanes. High quality and sufficient amount of evidence is warranted.

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Section: Discussionmentioning

confidence: 99%

Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

et al. 2021

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“…In other words, cooling will bring down tissue temperature causing vasoconstriction of blood vessels in distal limbs. The reduction of blood ow to the hands and feet means that there is less damage of chemotherapy agents incurred by nerve ber endings in the hands and feet and ultimately preventing the risk of CIPN (5,13). However, current methods for inducing cooling are based on the use of ice packs in the form of gloves and socks and ice-water baths to cool the hands and feet; methods which are di cult to control and can therefore be painful and intolerable for patients.…”

Section: Discussionmentioning

confidence: 99%

“…One of these mentioned side effects is damage to peripheral nerves in the body specially the hands and feet, known as chemotherapy-induced peripheral neuropathy (CIPN). Symptoms such as loss of sensation, burning, numbness and pain in the hands and feet have been reported which can increase the risk of fall injuries and occurrence of cuts and burns (2,5,6). Patients can also have di culties with ne motor skills, which makes it di cult to perform everyday tasks such as buttoning shirts, brushing teeth and typing on a phone (5,7).…”

Section: Introductionmentioning

confidence: 99%

Introduction of a Portable and Non-invasive Technology for Hand and Foot Cooling: A Preclinical Feasibility Study

Jazi¹,

Ralf²,

FazelBakhsheshi³

2021

Preprint

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Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is caused by damage to neural structures in distal limbs. CIPN can lead to reduced dose or cessation of chemotherapy. Cooling the hands/feet has shown to be effective in reducing or preventing CIPN. However, when using ice bath or ice gloves/socks is no way to maintain the targeted temperature and prevent ice from melting. Also, patients have difficulty tolerating the freezing temperatures over long periods of chemotherapy. The aim of this study was to test the cooling performance of a recently developed non-invasive system that can ultimately replace current cooling methods.Methods: COOLPREVENT circulates cold water at tolerable temperatures into malleable gloves/socks. As well, COOLPREVENT does not require replacing of melted ice. We administered a cooling protocol via COOLPREVENT on three healthy subjects for 60 minutes. Immediately before and after cooling, skin temperature in the hands and feet were measured. Level of discomfort was also recorded during the cooling process.Results: Results showed that COOLPREVENT reduce skin temperature by 14.5±3.8°C and 10.7±1.7°C in the hands and feet, respectively within 60 minutes without significant discomfort.Conclusion: Although our study is limited by the small number of subjects and participation of healthy individuals, but we can conclude that COOLPREVENT can be a safe and appropriate method for hand and foot cooling. We hope that these preliminary findings can pave the way to designing clinical trials we plan to conduct in the near future.

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“…Of these, the most promising intervention has been cryotherapy (7,8). In a recent meta-analysis on the effectiveness of cryotherapy by Bailey et al (94), it was noted that all seven trials assessed taxane-induced peripheral neuropathy, although the trial by Beijers et al also recruited patients on oxaliplatin (21). Given that cold exposure is generally avoided to prevent acute OIPN, it is interesting that this study explored cryotherapy for CIPN prevention including an oxaliplatin cohort.…”

Section: Pre-clinical Studies and Future Directionsmentioning

confidence: 99%

Prevention of Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

et al. 2022

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BackgroundOxaliplatin-induced peripheral neuropathy (OIPN) has significant clinical impact on the quality of life for cancer patients and is a dose limiting toxicity. Trials studying preventive measures have been inconclusive. A systematic review and meta-analysis were conducted to evaluate the existing pharmacological and non-pharmacological interventions to prevent chronic OIPN.MethodsLiterature databases PubMed-MEDLINE, Embase and Scopus, were searched from 1 Jan 2005 to 08 Aug 2020 and major conferences’ abstracts were reviewed for randomized controlled trials that examined the efficacy of any preventive measure for OIPN. The primary outcome measure was the incidence of chronic OIPN with a preventive intervention as compared to placebo or no intervention. The pooled risk ratio and its 95% confidence interval were calculated using a random effects model. A network meta-analysis was conducted to derive indirect evidence of any preventive effect of an intervention against placebo when original trials compared one intervention against another.ResultsForty-four trials were analyzed describing 29 chemoprotective interventions, including combinations, and 1 non-pharmacological intervention. Ratings were assessed via a combination of outcomes with quality assessment using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. Of the 30 interventions examined, there were six interventions supporting potential efficacy, 11 interventions with insufficient evidence and 13 interventions not recommended.ConclusionCurrently, there is insufficient certainty to support any intervention as effective in preventing OIPN. Of note is that most of these studies have focused on pharmacological interventions; non-pharmacological interventions are underexplored. Further research on ways to limit OIPN is needed.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=225095, Prospero Registration Number: CRD42021225095.

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Cryotherapy for the prevention of chemotherapy-induced peripheral neuropathy: A systematic review

Cited by 27 publications

References 27 publications

Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

Introduction of a Portable and Non-invasive Technology for Hand and Foot Cooling: A Preclinical Feasibility Study

Prevention of Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

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