Cryotherapy of Erosion of Cervix and Low Grade Squamous Intraepithelial Lesion

Abstract

Introduction: Cervical erosion and squamouse intraepithelial lesion of low grade are most common gynecological problems of women. These changes on cervix are cause of painful coitus and enhanced vaginal secretion. Cryotherapy is widely accepted method in treating these changes and sympthoms. Aim: The aim of this study is to examine the efficiency of cryotherapy in eliminating erosion of cervics and LSIL, as well as conditions following these states. Patients and methods: Cryotherapy was performed in 124 women with cervical erosion (N-74) and LSIL (N-50). Sympthoms that were followed are: vaginal secretion, abnormal vaginal bleeding and pain. Assessment of epithelisation of cervix and evaluation of sympthoms were done 4 and 6 weeks after cryotherapy and PAP test after 4 months in women with LSIL. Statistical method used in result processing was X2 test. Results: The average age of examined women is 37,75±8,2. Enhanced vaginal secretion had 87,09% (N-120), painful coitus 61,29% (N-76), pain in lesser pelvis 52,41% (N-65) and abnormal vaginal bleeding 28,22% (N-35). Erosion of cervix had 14% (N-7) of women with LSIL. After cryotherapy, enhanced vaginal secretion remained in 21,77% (N-27) of women, painful coitus remained in 8,06% (N-10), pain in lesser pelvis remained in 5,6% (N-7) and abnormal vaginal bleeding in 6,4% (N-8). Four weeks after cryotherapy, complete epithelisation of cervix was in 87,90% (N-109) and after six weeks in 93,54% (N-116) of examined women. LSIL was eliminated in 92% (N-46) of women after cryotherapy and in 8% (N-4) results remained the same. Conclusion: Cryotherapy is successful method of elimination of cervical erosion, LSIL and pains with enhanced vaginal secretion.

Could tranexamic acid be a suitable alternative to cryotherapy for symptomatic cervical ectopy? Results from a randomized clinical trial

“…17,18 There are many bodies of evidence that support the effectiveness of this method in curing the symptoms of cervical ectropion. 3,[19][20][21] In the study by Yildiz et al, cryotherapy had a positive impact on the improvement of vaginal discharge, post-coital bleeding, and pelvic pain, which confirmed our findings. 3 Another study showed the highest success rate of cryotherapy in women with abundant leukorrhea but the lowest in women with recurrent cervicitis, and pelvic pain.…”

“…After this treatment, the ablated tissue becomes crusty and the process of re‐epithelialization begins 17,18 . There are many bodies of evidence that support the effectiveness of this method in curing the symptoms of cervical ectropion 3,19–21 . In the study by Yildiz et al., cryotherapy had a positive impact on the improvement of vaginal discharge, post‐coital bleeding, and pelvic pain, which confirmed our findings 3 .…”

Evaluation of efficacy and safety of cryotherapy in benign and premalignant cervical lesion

“…It must be considered that there is no difference in persistence of symptoms between inflammatory group and LSIL (CIN 1) group, as observed by Jahic et al 22 Similar findings were also found in a study done by Katakdhond et al and Jahic et al 4,22 Mohanty et al recorded that cryotherapy eliminates enhanced vaginal secretion and pain in 98% 12 weeks after the treatment. 16 The efficacy of present study is 91.9% and is comparable with most studies.…”

“…Size of lesion and location of lesion distribution described in Table 1. 4,[13][14][15][16] In another study conducted by Patil et al abnormal vaginal discharge was found in 55% of patients and this disparity might be because of different prevalence in the institute where the study was conducted. 17 Hence, abnormal white discharge was the main indication of cryotherapy among all patients.…”

Cytological, Colposcopic and Pathohistological Correlation of HSIL and ASC H Findings

“…Cervical carcinoma can be prevented successfully if the preceding changes like atypical (ASC-H) and squamous lesions of high grade (HSIL) are discovered in time. It is considered that it takes around 10 years in order for a low grade lesion to develop into cervical carcinoma, although in practice it comes to a faster development of this carcinoma ( 6 ). Cytology and colposcopy are used for screening of cervical carcinoma, whereas a definitive diagnosis is concluded based on pathohistological findings i.e.…”