Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis

Association between prurigo nodularis and malignancy in middle-aged adults

“…Also, we cannot draw conclusions about the causal relationship between PN and malignancy from these data. However, case reports have shown that PN can improve with cancer treatment, [2][3][4] suggesting that PN might be downstream. In the case of hematologic malignancies, PN might be the result of inflammatory infiltration of the skin, leading to pruritus and excoriation.…”

“…The SCI was used, as it is disease specific to NMSC and has been previously validated in a dermatologic surgery setting. 3 A 5-point response format was used to assess the extent to which each item described the feelings of the patient, with 1 meaning very much and 5 meaning not at all and a higher score indicating better QOL. Patients with diagnosed NMSC who were attending the Brigham and Women's Hospital Mohs and Dermatologic Surgery Center from March 2014 through March 2015 were eligible for participation in the study.…”

Local management of anogenital warts in immunocompetent adults: Systematic review and pooled analysis of randomized-controlled trial data

“…CRD42015025827). 3 In total, 70 RCTs involving 9931 individual patients were included. A high risk of bias was identified in 66 RCTs.…”

“…Trichloroacetic acid was associated with a high clearance rate, a low recurrence rate, and few side effects compared with cryotherapy. 3 The latest guidelines 1 include 5-fluorouracil cream but fail to mention potassium hydroxide. Our analysis yielded a high clearance rate and a low recurrence rate for both treatments, suggesting that potassium hydroxide could also be included as first-line treatment in future guidelines; besides, 5-fluorouracil cream caused more low-and medium-grade local side effects than potassium hydroxide.…”

Local Management of Anogenital Warts in Non-Immunocompromised Adults: A Network Meta-Analysis of Randomized Controlled Trials

“…These recommendations, however, are based on head-to-head randomized trials or on expert advice. Furthermore, RCTs comparing several major treatments for AGWs (cryotherapy [12] vs podophyllotoxin cream or gel, imiquimod vs TCA, CO 2 laser vs surgery or electrosurgery, etc.) are lacking [10,[13][14][15] and may never be performed (because they are costly, time-consuming, less attractive than new treatments, etc.).…”