Cryptocurrency investment approaches continue to evolve rapidly. Traditionally, cryptocurrency holders tend to actively support up to several distinct projects, focusing their selection criteria on specific project characteristics, project team and community, existing markets and liquidity levels, as well as the perception of each unique project’s broadly understood “mission and vision” and “future potential.” In this chapter, we will explore an index-based investment strategy as an alternative to the more traditional single- or oligo-asset approaches. In the index-based paradigm, multi-asset strategy involves equalization and redistribution of risk exposure across multiple, pre-vetted portfolio positions. This strategy, novel to the cryptocurrency space, also involves risk reduction through cost averaging, dilution of cyber security-related risk(s), as well as mitigation of liquidity restrictions related to individual-position market liquidity characteristics. Additional discussion of software platforms, including both custodial and non-custodial wallets, and the associated risk-benefit considerations, will also be included in this manuscript.