1999
DOI: 10.1136/jcp.52.12.928
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Cryptococcal meningitis in an HIV negative patient with systemic sarcoidosis.

Abstract: A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with intravenous amphotericin B but died within two weeks of admission. Necropsy revealed lesions in the lungs, liver, spleen, lymph nodes, small intestine, and bone marrow consistent with sarcoidosis. Mi… Show more

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Cited by 25 publications
(13 citation statements)
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“…In this case, the high cell count could be due to a better immune status. Reports of Cryptococcal meningitis in association with sarcoidosis, idiopathic CD4 lymphopenia and neoplastic disease is known [10,[11][12][13]. Cryptococcal meningitis can occur in immunocompetent individuals also [14].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In this case, the high cell count could be due to a better immune status. Reports of Cryptococcal meningitis in association with sarcoidosis, idiopathic CD4 lymphopenia and neoplastic disease is known [10,[11][12][13]. Cryptococcal meningitis can occur in immunocompetent individuals also [14].…”
Section: Discussionmentioning
confidence: 99%
“…About 6% -10% of patients with AIDS have cryptococcal meningitis as the first AIDS defining illness [1,2,7,9]. However, the condition is known to occur in other immunocompromised conditions [10,11,12] as also in immunocompetent individuals [13] Cryptococcus neoformans, the organism causing the condition is present ubiquitously and affects those prone to it. It is a yeast like fungus, round or oval, usually 4-6 um in diameter with double wall and distinct capsule.…”
Section: Introductionmentioning
confidence: 99%
“…Neurological dysfunction as the first manifestation of AIDS has been found in 10-20% of symptomatic HIV infections (Botha and Wessels, 1999). In most cases neurologic involvement in patients with AIDS is due to infection with Mycobacterium tuberculosis and Cryptococcus neoformans and they account for 75% cases of meningitis; because of their frequency and morbidity, they should always be considered first in evaluation of a headache in a patient with AIDS but only 1.9% of cases initially present with cryptococcal infection (Hong et al, 2007).…”
Section: Resultsmentioning
confidence: 99%
“…8 Cryptococcal meningitis is the most common manifestation of infection with C. neoformans; however, other sites can be affected, including the lungs where these organisms can cause fungal pneumonia. 3,7 Bone marrow cryptococcosis is a classical, albeit relatively infrequent, presentation in patients with acquired immunodeficiency syndrome (AIDS) and is only rarely seen in patients with sarcoidosis. 1,2,10 Systemic sarcoidosis is associated with chronic T-cell deficiency which is exacerbated by prolonged steroid therapy in patients with this disease.…”
mentioning
confidence: 99%
“…9 Sarcoidosis is an idiopathic granulomatous disease of unknown etiology in which patients have an increased risk of opportunistic infection related both to sarcoidosis itself and to the use of steroid therapy in the treatment of this disease. [3][4][5][6] Systemic cryptococcosis is a life-threatening disease occurring in immunocompromised patients. 8 Cryptococcal meningitis is the most common manifestation of infection with C. neoformans; however, other sites can be affected, including the lungs where these organisms can cause fungal pneumonia.…”
mentioning
confidence: 99%