Cryptococcosis

Reagan, Krystle L.; Krockenberger, Mark; Sykes, Jane E.

doi:10.1016/b978-0-323-50934-3.00082-3

Cited by 2 publications

(1 citation statement)

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“…In such refractory cases, combination therapy with an azole and TRB ( Table 1 ), or TRB monotherapy, may be effective. 83 If LCAT titres decline four- to five-fold and then remain static despite these approaches, treatment response may be deemed adequate if accompanied by clinical remission. 83 Serum LCAT titres should be monitored and treatment re-instituted if they increase.…”

Section: Management Of Invasive Fungal and Fungal-like Infections In ...mentioning

confidence: 99%

Invasive fungal infections and oomycoses in cats 2. Antifungal therapy

Barrs,

Hobi,

Wong

et al. 2024

Journal of Feline Medicine and Surgery

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Clinical relevance: Invasive fungal infections (IFIs) and oomycoses (hereafter termed invasive fungal-like infections [IFLIs]) are characterised by penetration of tissues by fungal elements. The environment is the most common reservoir of infection. IFIs and IFLIs can be frustrating to treat because long treatment times are usually required and, even after attaining clinical cure, there may be a risk of relapse. Owner compliance with medication administration and recheck examinations can also decline over time. In addition, some antifungal drugs are expensive, have variable interpatient pharmacokinetic properties, can only be administered parenterally and/or have common adverse effects (AEs). Despite these limitations, treatment can be very rewarding, especially when an otherwise progressive and fatal disease is cured. Aim: In the second of a two-part article series, the spectrum of activity, mechanisms of action, pharmacokinetic and pharmacodynamic properties, and AEs of antifungal drugs are reviewed, and the treatment and prognosis of specific IFIs/IFLIs - dermatophytic pseudomycetoma, cryptococcosis, sino-orbital aspergillosis, coccidioidomycosis, histoplasmosis, sporotrichosis, phaeohyphomycosis, mucormycosis and oomycosis - are discussed. Part 1 reviewed the diagnostic approach to IFIs and IFLIs. Evidence base: Information on antifungal drugs is drawn from pharmacokinetic studies in cats. Where such studies have not been performed, data from ‘preclinical’ animals (non-human studies) and human studies are reviewed. The review also draws on the wider published evidence and the authors’ combined expertise in feline medicine, mycology, dermatology, clinical pathology and anatomical pathology. Abbreviations for antifungal drugs: AMB (amphotericin B); FC (flucytosine); FCZ (fluconazole); ISA (isavuconazole); ITZ (itraconazole); KCZ (ketoconazole); PCZ (posaconazole); TRB (terbinafine); VCZ (voriconazole).

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Section: Management Of Invasive Fungal and Fungal-like Infections In ...mentioning

confidence: 99%