Cryptococcosis: An unusual opportunistic infection complicating B cell lymphoproliferative disorders

Melzer, Mark; Colbridge, M J; Keenan, Fiona; Stainsby, D; Ong, Edmund

doi:10.1016/s0163-4453(98)80018-2

Cited by 9 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors report that flucytosine does not contribute to the cure, but would only be efficient in the prevention of recurrences 30,32 . 24,27 . KORFEL et al, in 1998, gave the first account of antimycotic treatment of cryptococcosis with liposome amphotericin B in patients with Hodgkin's disease.…”

Section: Discussionmentioning

confidence: 99%

“…Cryptococcosis, also known as torulosis, Busse -Buschke's disease and European blastomycosis is a cosmopolitan illness, with opportunist behavior 2,11,12,14,20,24,29 .…”

Section: Introductionmentioning

confidence: 99%

“…Many cases described are associated to the immunosuppression, due to lymphoma 17 , chronic leukemia 23,24 , transplants of organs 11 , use of corticosteroid 27,33 , immunosuppressive drugs 14,27 , systemic lupus erythematosus 28 , diabetes mellitus 14,23 , Cushing's syndrome 5 and, more recently, related with acquired immunodeficiency syndrome (Aids) 1,2,11,15,25,29 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disseminated cutaneous cryptococcosis in a patient with AIDS

Dinato

Dinato²,

Nakanishi³

et al. 2006

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYThe authors study a patient carrying Aids, with exuberant dermatological manifestations of cryptococcosis. They stress the therapeutic effectiveness of short-term amphotericin B. The authors reviewed cases of cutaneous infection with Cryptococcus reported in the national and international literature, verifying that the frequency has increased with the AIDS epidemic. Also, they discuss about the differential diagnosis with some cases of dermatosis, particularly with the disseminated giant molluscum contagiosum. In relation to the therapy, they affirm that the choice of drug depends on the organ involved, as well as the immune state of the patient.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Cryptococcosis, also known as torulosis, Busse -Buschke's disease and European blastomycosis is a cosmopolitan illness, with opportunist behavior 2,11,12,14,20,24,29 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disseminated cutaneous cryptococcosis in a patient with AIDS

Dinato

Dinato²,

Nakanishi³

et al. 2006

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…Although these syndromes are characterized by defects in acquired, T-cell-dependent antibody responses, they are complex disorders that also feature a central defect in the memory B-cell repertoire (3,4). Similarly, the patients that appear to be at the highest risk for cryptococcosis often have B-cell defects in addition to impaired cell-mediated immunity, such as patients with HIV infection, and, in the pre-AIDS era, patients with B-cell or hematologic malignancies (39,47). Mouse models of experimental cryptococcosis have also implicated B cells in resistance to C. neoformans (5,56) while also demonstrating that antibody efficacy against lethal C. neoformans requires CD4…”

Section: The Central Importance Of Intact Cd4mentioning

confidence: 99%

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Subramaniam¹,

French

Pirofski

2005

Clin Vaccine Immunol

View full text Add to dashboard Cite

We determined total and Cryptococcus neoformans glucuronoxylomannan (GXM)-reactive antibody repertoires of human immunodeficiency virus (HIV)-infected and HIV-uninfectedThe results showed that HIV-infected subjects had significantly lower levels of IgM to GXM but higher levels of total immunoglobulin and IgG and IgA to GXM than those of HIV-uninfected subjects. HIV-infected subjects with a history of pneumonia had higher levels, and those with a history of herpes zoster had lower levels of GXM-binding antibodies than subjects with no history of either disease. Minimal to no cross-reactivity was demonstrated between antibodies to GXM and polysaccharides in a pneumococcal vaccine. No significant differences between the antibody repertoires of HIV ؉ CM ؉ and HIV ؉ CM ؊ subjects were identified, but among subjects without a history of pneumonia, there was a trend towards lower V H 3-positive antibody levels among HIV ؉ CM ؉ than among HIV ؉ CM ؊ subjects. Our findings demonstrate an association between previous infectious diseases and differences in the total and GXM-reactive antibody repertoires of HIV-infected subjects and suggest the question of whether certain microbes modulate subsequent antibody responses to GXM deserves further study.

show abstract

“…Cryptococcosis most commonly occurs in those with lymphoma [137][138][139][140][141], chronic leukemias [142,143], and other hematologic malignancies such as acute leukemia [144][145][146] and multiple myeloma [147]. A minority of cases occur in patients with solid tumors, especially those receiving corticosteroids [138,148].…”

Section: Cryptococcus Speciesmentioning

confidence: 99%

Central Nervous System Infections in Cancer Patients and Hematopoietic Stem Cell Transplant Recipients

Hoffman

Stosor

2014

Cancer Treatment and Research

View full text Add to dashboard Cite

Central nervous system (CNS) infections in cancer patients present a diagnostic and therapeutic challenge for clinicians. While CNS infections are not frequent complications of cancer, its therapies, or hematopoietic stem cell transplantation, the importance of CNS infections lies in their propensity to result in profound morbidity and substantial mortality in this vulnerable patient population. With an expanding population of patients with malignant disease undergoing more potent and aggressive therapies and with the advent of newer immunomodulatory agents, the incidence of CNS infectious complications is likely to rise. This chapter will summarize the clinical and diagnostic evaluation of potential infections of the CNS in these patients and will discuss particular pathogens of interest with regard to this at-risk patient population.

show abstract

Cryptococcosis: An unusual opportunistic infection complicating B cell lymphoproliferative disorders

Cited by 9 publications

References 5 publications

Disseminated cutaneous cryptococcosis in a patient with AIDS

Disseminated cutaneous cryptococcosis in a patient with AIDS

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Central Nervous System Infections in Cancer Patients and Hematopoietic Stem Cell Transplant Recipients

Contact Info

Product

Resources

About