Cryptococcosis Presenting as a Colonic Ulcer in a Kidney Transplant Recipient: A Case Report

Cicora, Federico; Petroni, J.; Roberti, Javier

doi:10.1016/j.transproceed.2015.09.041

Cited by 5 publications

(11 citation statements)

References 11 publications

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“…e correlation between immunocompromised and intestinal cryptococcosis is well documented. Patients with advanced stages of HIV (CD4 < 200), with malignant processes (solid or hematological tumors), treatment with immunosuppressants [4,6], organ-transplanted [11], or cirrhotic [9,12] are considered as high-risk subjects.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Cryptococcosis Associated with Intestinal Lymphangiectasia

Naranjo-Saltos¹,

Hallo

Hallo³

et al. 2020

Case Reports in Medicine

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Intestinal lymphangiectasia is a pathological dilation of enteric lymphatic vessels resulting in lymph leakage to the intestinal lumen. This chronic lymph leakage leads to a state of immunosuppression secondary to the loss of humoral and cellular components of the immune system and represents a potential risk factor for opportunistic infections. We report a case of protein-losing enteropathy in a seemingly immunocompetent patient. An intestinal histopathological study revealed the unusual association of lymphangiectasia and intestinal cryptococcosis. Although cryptococcal infection is common in immunocompromised patients, intestinal involvement is rarely reported. We found no reports on the association of intestinal cryptococcosis in patients with lymphangiectasia. This case report is the first to describe intestinal cryptococcosis associated with intestinal lymphangiectasia.

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Section: Discussionmentioning

confidence: 99%

“…However, ulcers can be similar to those produced in malignancy, other infections (Cytomegalovirus, Toxoplasma gondii, Leishmania donovani, etc. ), or Crohn's disease [3,7,11,15].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Cryptococcosis Associated with Intestinal Lymphangiectasia

Naranjo-Saltos¹,

Hallo

Hallo³

et al. 2020

Case Reports in Medicine

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“…Pulmonary involvement is also common 2. Lesions have also been described in the brain, lungs, skin, bloodstream,2 3 kidneys,4 prostate,5 6 eyes,7 sinuses,8 colon,9 liver10 and blood vessels as vasculitis 16…”

Section: Discussionmentioning

confidence: 99%

“…It is the third leading cause of fungal infection in solid organ transplant recipients, following aspergillosis and candidiasis, with an overall incidence of 2.8% in this population 2 3. Cases most frequently involve the central nervous system or the lungs, but multiple other sites of infection have been documented including the skin, bloodstream,2 3 kidneys,4 prostate,5 6 eyes,7 sinuses,8 colon9 and liver 10. About 5% of all cryptococcal infections present with osteomyelitis 11.…”

Section: Introductionmentioning

confidence: 99%

Cryptococcus neoformansosteomyelitis and intramuscular abscess in a liver transplant patient

2017

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is an important pathogen that can cause severe illness and mortality in immunocompromised patients. We highlight here the case of a 53-year-old man presenting to hospital 4 years postliver transplant with fever, acute renal failure and a medial thigh lesion. Initially treated as bacterial sepsis, the patient failed to improve on broad-spectrum antibiotics. Further investigations revealed disseminated cryptococcemia complicated by patellar osteomyelitis and an intramuscular abscess. Unfortunately, although the patient initially showed signs of clinical improvement after starting standard antifungal agents, he deteriorated and died secondary to acute renal failure. Osteomyelitis is a rare manifestation of cryptococcal infection for which there is often a significant delay to diagnosis and treatment. This is the fourth reported case of cryptococcal osteomyelitis in a liver transplant patient and underlines the importance of considering fungal infections in the differential diagnosis of osseous lesions in solid organ transplant and other immunocompromised patients.

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“…2 Colonic involvement as the unique manifestation of Cryptococcosis is extremely infrequent. 3 Colonic infection may have several presentations, including a solid malignant-like mass, ulcers, or nonspecific signs of inflammation. 2 Pathology is, therefore, essential for diagnosis by identifying encapsulated PAS-positive circular bodies.…”

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confidence: 99%