Cryptogenic and Secondary Organizing Pneumonia

Drakopanagiotakis, Fotios; Paschalaki, Koralia; Abu‐Hijleh, Muhanned; Aswad, Bassam I.; Karagianidis, Napoleon; Kastanakis, Emmanouil; Braman, Sidney S.; Polychronopoulos, Vlasis

doi:10.1378/chest.10-0883

Cited by 151 publications

(121 citation statements)

References 22 publications

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“…In the present group, pleuritic chest pain was determined in six cases. The prevalence of this symptom was close to the rates found in some previous studies (3,13).…”

Section: Discussionsupporting

confidence: 89%

Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature

Niksarlıoğlu¹,

Özkan²,

Bakan³

et al. 2016

Turk J Med Sci

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Background/aim: We evaluated patients with cryptogenic organizing pneumonia (COP) who attended our clinic. Materials and methods:We retrospectively investigated the clinical and radiological findings, diagnostic methods, treatment, and follow-up outcomes of 17 patients who had been histopathologically diagnosed with COP. Results:The mean age of the patients was 49.8 ± 10.4 years. The most common symptom was cough (n = 15; 88.2%) and the most common radiological finding (n = 10) was consolidation in the inferior lobes on thoracic computed tomography. The diagnosis of COP was made by open lung biopsy in 11 (64.7%) patients, transbronchial biopsy in 5 (29.4%), and video-assisted thoracoscopic surgery biopsy in 1 (5.9%). The mean follow-up period was 28.7 ± 25.0 (range: 3-85) months. Twelve patients received oral corticosteroid therapy and seven of them improved without any fibrotic changes. One patient refused treatment; a chest radiography of that patient was found to be normal at the end of the 20-month follow-up period. Three patients received no other therapy, as the lesion had been completely excised. Conclusion:Common symptoms included cough and dyspnea, while the main radiological presentation of COP was consolidation. Corticosteroids are a good treatment option in general, but relapse may occur.

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“…In the present group, pleuritic chest pain was determined in six cases. The prevalence of this symptom was close to the rates found in some previous studies (3,13).…”

Section: Discussionsupporting

confidence: 89%

Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature

Niksarlıoğlu¹,

Özkan²,

Bakan³

et al. 2016

Turk J Med Sci

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“…They reported the causes of secondary OP to be infections (most commonly by Streptococcus pneumoniae and Haemophilus influenza), drug use (amiodarone, nitrofurantoin, busulfan, and methotrexate), cancers (breast, lung, and non-Hodgkin lymphoma), connective tissue diseases (rheumatoid arthritis, polymyalgia rheumatica, and Sjögren's syndrome), and radiotherapy in 46% of their patients [6]. The causes defined in 21 secondary OP patients in the series by Drakopanagiotakis et al [7] were drug use (29%), rheumatic diseases (20%), breast and colon cancers (24%), lymphoma (14%), renal transplantation (5%), and infections (9%). The frequency of OP was reported to be 2%-4.8% in rheumatoid arthritis patients [12].…”

Section: Discussionmentioning

confidence: 99%

“…When the OP pattern is detected as a diffuse and major finding, it expresses the disease [3,4]. OP has been investigated in terms of its cryptogenic and secondary forms and its radiological features, but no defnite conclusions can be drawn from these studies [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Organizing Pneumonia as a Histopathological Term

et al. 2017

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“…The use of antibiotic therapy for the empirical treatment of infection is ineffective, (3-6) although macrolides are used in the treatment of patients with mild symptoms or as an adjuvant therapy, given their immunomodulatory properties. (9,10) The disease usually develops after a prodrome, wherein the patient shows flu-like symptoms, including fever, fatigue, dry cough and dyspnea.…”

Section: Discussionmentioning

confidence: 99%

Insuficiência respiratória aguda causada por pneumonia em organização secundária à terapia antineoplásica para linfoma não Hodgkin

Santana

Amorim

Soares³

et al. 2012

Rev. bras. ter. intensiva

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Interstitial lung diseases belong to a group of diseases that typically exhibit a subacute or chronic progression but that may cause acute respiratory failure. The male patient, who was 37 years of age and undergoing therapy for non-Hodgkin's lymphoma, was admitted with cough, fever, dyspnea and acute hypoxemic respiratory failure. Mechanical ventilation and antibiotic therapy were initiated but were associated with unfavorable progression. Thoracic computed tomography showed bilateral pulmonary "ground glass" opacities. Methylprednisolone pulse therapy was initiated with satisfactory response because the patient had used three drugs related to organizing pneumonia (cyclophosphamide, doxorubicin and rituximab), and the clinical and radiological symptoms were suggestive. Organizing pneumonia may be idiopathic or linked to collagen diseases, drugs and cancer and usually responds to corticosteroid therapy. The diagnosis was anatomopathological, but the patient's clinical condition precluded performing a lung biopsy. Organizing pneumonia should be a differential diagnosis in patients with apparent pneumonia and a progression that is unfavorable to antimicrobial treatment.

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Cryptogenic and Secondary Organizing Pneumonia

Cited by 151 publications

References 22 publications

Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature

Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature

Organizing Pneumonia as a Histopathological Term

Insuficiência respiratória aguda causada por pneumonia em organização secundária à terapia antineoplásica para linfoma não Hodgkin

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