Cryptogenic Organizing Pneumonia: IL-1β, IL-6, IL-8, and TGF- β1 Serum Concentrations and Response to Clarithromycin Treatment

Radzikowska, E; Roży, Adriana; Jagus, Paulina; Wiatr, Elżbieta; Gawryluk, Dariusz; Chorostowska‐Wynimko, Joanna; Roszkowski‐Śliż, Kazimierz

doi:10.1007/5584_2016_223

Cited by 13 publications

(14 citation statements)

References 23 publications

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“…84 Costimulation of TGF-β with IL-6 is required for Th17 cell differentiation. 85 The TGF-β1 content in the serum of TB patients is higher than that in HC controls, and the serum level of TGF-β1 is directly related to the bacterial load and radiological severity. 86 Moreover, PBMCs from TB patients produce more TGF-β than those from LTBI under Mtb antigen stimulation.…”

Section: Mtb Infection Regulates the Expression Of Upstream Cytokinesmentioning

confidence: 96%

The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection

2017

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Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development. Here, we review Th17-related cytokines/Th17-like cells, networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis (Mtb) infection. Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis (TB). In addition, there is evidence that immune responses of the signal transducer and activator of transcription 3 (STAT3) signal pathway and Th17-like T-cell subsets are dysregulated or destroyed in patients with TB. Furthermore, Mtb infection can impact upstream cytokines in the STAT3 pathway of Th17-like responses. Based on these findings, we discuss the need for future studies and the rationale for targeting Th17-related cytokines/signals as a potential adjunctive treatment.

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Section: Mtb Infection Regulates the Expression Of Upstream Cytokinesmentioning

confidence: 96%

The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection

2017

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“…Macrolides (clarithromycin and azithromycin) have been reported to be effective in the treatment of organising pneumonia and associated with fewer side effects and relapses, particularly in patients with normal pulmonary function 13. Inflammatory cytokines produced by alveolar macrophages including interleukin (IL)-6, IL-8 and transforming growth factor-β1 play an important role in the pathogenesis of organising pneumonia 14. Macrolides inhibit cytokine production by the alveolar macrophages decreasing their concentration in the serum and bronchoalveolar lavage in patients with organising pneumonia 14–16.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory cytokines produced by alveolar macrophages including interleukin (IL)-6, IL-8 and transforming growth factor-β1 play an important role in the pathogenesis of organising pneumonia 14. Macrolides inhibit cytokine production by the alveolar macrophages decreasing their concentration in the serum and bronchoalveolar lavage in patients with organising pneumonia 14–16. The anti-inflammatory effects of macrolides are the basis of their effectiveness in the treatment of organising pneumonia14–16 and other diseases including chronic obstructive pulmonary disease, cystic fibrosis and panbronchiolitis.…”

Section: Discussionmentioning

confidence: 99%

“…Macrolides inhibit cytokine production by the alveolar macrophages decreasing their concentration in the serum and bronchoalveolar lavage in patients with organising pneumonia 14–16. The anti-inflammatory effects of macrolides are the basis of their effectiveness in the treatment of organising pneumonia14–16 and other diseases including chronic obstructive pulmonary disease, cystic fibrosis and panbronchiolitis. Macrolides have been successfully used to treat cryptogenic and secondary organising pneumonia either alone or in combination with corticosteroids 17–19.…”

Section: Discussionmentioning

confidence: 99%

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Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

et al. 2019

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Acute fibrinous organising pneumonia is distinct from the classic diffuse alveolar damage, organising pneumonia and eosinophilic pneumonia. A 52-year-old woman presented with fever, productive cough, night sweats and left-sided pleuritic chest pain for a week. Physical examination was significant only for decreased breath sounds in the left infraclavicular area laterally. Imaging studies revealed a peripheral thick-walled left upper lobe cavitary lesion, left lower lobe consolidation and an enlarged subcarinal lymph node. She was treated with doxycycline for 10 days without improvement. Pertinent laboratory tests, microbiologic workup and fibre-optic bronchoscopy were non-diagnostic and a CT-guided left upper lobe lung biopsy revealed acute fibrinous organising pneumonia. She was treated with azithromycin with complete resolution of symptoms. To our knowledge, this is the first reported case of acute fibrinous organising pneumonia presenting as a cavitary lung lesion and the first with treatment response to azithromycin.

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“…These cytokines are essential chemotactic factors for neutrophils and play important roles in the pathogenesis of COP[ 2 , 36 , 39 – 41 ]. Previous data showed potential activities of macrolides in patients with COP [ 21 – 26 , 40 , 41 ]. The aim of this study was to compare the results of CAM versus prednisone (PRE) in patients with OP.…”

Section: Introductionmentioning

confidence: 99%

Cryptogenic organizing pneumonia—Results of treatment with clarithromycin versus corticosteroids—Observational study

Radzikowska¹,

Wiatr²,

Langfort³

et al. 2017

PLoS ONE

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BackgroundCryptogenic organizing pneumonia (COP) is a clinicopathological syndrome of unknown origin. Corticosteroids are the standard treatment, but clarithromycin (CAM) is also effective. The aim of this observational retrospective study was to compare the results of CAM versus prednisone (PRE) treatment in patients with biopsy-proven OP without respiratory insufficiency.Material and methodsIn a 15-year period, 40 patients were treated with CAM (500 mg twice daily orally for 3 months) and 22 with PRE (mean initial dose of 0.67 ± 0.24 mg/kg/d for a mean of 8.59 ± 3.05 months).ResultsThe clinical presentation, laboratory, and radiological findings did not differ markedly between patients treated with CAM and PRE, with the exception of a higher frequency of sweats (55% vs. 23%; p < 0.015), ground glass opacities (95% vs. 50%; p <0.0001) and nodular lesions (45% vs. 18%; p = 0.036) in the CAM group. A complete response was achieved in 35(88%) patients treated with CAM and in all treated with PRE. Patients treated with PRE relapsed more frequently than those treated with CAM (54.5% vs. 10%; p < 0.0001). Corticosteroid-related adverse events were noticed in 8(6.5%) patients (with one death), but CAM caused only one (2.5%) allergic reaction. A FVC >80% identified patients who might be successfully treated with CAM with a sensitivity of 60% and a specificity of 88.57% (AUC 0.869; 95% CI 0.684–1; p = 0.008); the figures for the FEV1 were >70%, a sensitivity of 60%, and a specificity of 91.43% (AUC 0.809; 95%CI 0.609–1; p = 0.027).ConclusionsCAM can be used to treat COP patients in whom the pulmonary function parameters are within normal limits. Such therapy is shorter, better tolerated, and associated with fewer adverse events and relapses than is PRE. However, the therapy is ineffective in some patients.

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Cryptogenic Organizing Pneumonia: IL-1β, IL-6, IL-8, and TGF- β1 Serum Concentrations and Response to Clarithromycin Treatment

Cited by 13 publications

References 23 publications

The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection

The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection

Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

Cryptogenic organizing pneumonia—Results of treatment with clarithromycin versus corticosteroids—Observational study

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