Cryptogenic Organizing Pneumonitis During Oxaliplatin Chemotherapy for Colorectal Cancer

Garrido, Marcelo; O'Brien, Andrés; González, Sergio; Clavero, José Miguel; Orellana, Omar

doi:10.1378/chest.07-0536

Cited by 45 publications

(33 citation statements)

References 8 publications

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“…3 Other forms of bleomycin-induced lung injury include interstitial pneumonitis, organizing pneumonia, and hypersensitivity pneumonitis. [4][5][6] Although lung injury is commonly associated with high bleomycin cumulative doses of over 400 units, it has also been reported with low doses of less than 50 units. 7 Though the exact mechanism by which bleomycin results in lung injury is unclear, free-radicalinduced oxidation is considered the primary mechanism.…”

Section: Discussionmentioning

confidence: 99%

Beyond Conventional Therapy: Role of Pulse Steroids in Bleomycin Induced Lung Injury

Gupta¹,

Ettinger

2013

Respir Care

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Section: Discussionmentioning

confidence: 99%

Beyond Conventional Therapy: Role of Pulse Steroids in Bleomycin Induced Lung Injury

Gupta¹,

Ettinger

2013

Respir Care

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“…Recently, a number of cases of oxaliplatin-induced interstitial lung disease were reported (table 1) [4,5,6,7,8,9,10]. Presumptive diagnoses varied, e.g.…”

Section: Discussionmentioning

confidence: 99%

Organizing Pneumonia Associated with Oxaliplatin-Combined Chemotherapy: A Case Report

Lee¹,

In²,

Kim

et al. 2011

Med Princ Pract

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Objective: To report a case of oxaliplatin-combined chemotherapy-induced interstitial lung disease. Clinical Presentation and Intervention: A 57-year-old man was referred complaining of dyspnea and fever after treatment with an oxaliplatin-combined chemotherapeutic agent for metastatic colorectal cancer. Fever development and spontaneous subsidence were observed during the chemotherapeutic course repeatedly until the 9th cycle. A computer-tomographic (CT) scan revealed bilateral, peripherally distributed, patchy consolidation suggestive of an interstitial lung disease. As a confirmative step, video-assisted thoracoscopic surgical biopsy was attempted; the characteristic intraluminal organizing fibrous plug in the bronchioles and alveoli was seen. Corticosteroid therapy was administered, which rapidly improved the patient’s symptoms and chest CT findings. Conclusion: This case showed that oxaliplatin may be implicated in the etiology of interstitial lung disease, since withdrawal of the drug resulted in improvement of interstitial lung disease.

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“…Secondary OP can be related to different types of medications, including amiodarone [35,36], acebutolol [35], nitrofurantoin [37], ticlopidine [38], and anticancer drugs [39][40][41]. OP can occur in patients with different malignancies [10,42,43] or after radiation therapy [44].…”

Section: Discussionmentioning

confidence: 99%

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

et al. 2011

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Cryptogenic Organizing Pneumonitis During Oxaliplatin Chemotherapy for Colorectal Cancer

Cited by 45 publications

References 8 publications

Beyond Conventional Therapy: Role of Pulse Steroids in Bleomycin Induced Lung Injury

Beyond Conventional Therapy: Role of Pulse Steroids in Bleomycin Induced Lung Injury

Organizing Pneumonia Associated with Oxaliplatin-Combined Chemotherapy: A Case Report

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

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