Cryptopleurine, an Active Antiviral Alkaloid from Boehmeria cylindrica (L.) Sw. (Urticaceae)

Krmpotic, E.; Farnsworth, Norman R.; Messmer, W M

doi:10.1002/jps.2600610945

Cited by 36 publications

(15 citation statements)

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“…17) and the related alkaloids julandine and 3,4-dimethoxy-w--(piperid-2-yl)acetophenone are highly active against Candida species (Al-Shamma et al, 1982). Cryptopleurine and derivatives are active against fungi (Foldeak, 1971), cytotoxic (Hoffmann et al, 1978), and have antiviral activity (Krmpotic et al, 1972). Their effect on the protein-synthesizing system in some microorganisms was studied by Haslam et al (1968).…”

Section: Miscellaneousmentioning

confidence: 98%

Antimicrobially Active Alkaloids

Verpoorte¹

1998

Alkaloids

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Section: Miscellaneousmentioning

confidence: 98%

Antimicrobially Active Alkaloids

Verpoorte¹

1998

Alkaloids

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“…Other antivirals include the tannin and non-tannin polyphenols from M. officinalis [138,139], an alkaloid fraction from Narcissus [140], and the hymnemic acids capable of viral modulation [141]. Krmpotic and colleagues reported in 1972 [142] the isolation of cryptopleurine (CID: 92765), an antiviral alkaloid from Boehmeria cylindrica (Urticaceae), highly active against DNA animal viruses, such as HSV-1. Although this compound displayed no activity against some of the RNA viruses tested, such as Coxsackie B-5 and polio type I viruses.…”

Section: Antivirals From Plantsmentioning

confidence: 99%

Antivirals against animal viruses

Villa

Feijoo-Siota

Rama

et al. 2017

Biochemical Pharmacology

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Antivirals are compounds used since the 1960s that can interfere with viral development. Some of these antivirals can be isolated from a variety of sources, such as animals, plants, bacteria or fungi, while others must be obtained by chemical synthesis, either designed or random. Antivirals display a variety of mechanisms of action, and while some of them enhance the animal immune system, others block a specific enzyme or a particular step in the viral replication cycle. As viruses are mandatory intracellular parasites that use the host's cellular machinery to survive and multiply, it is essential that antivirals do not harm the host. In addition, viruses are continually developing new antiviral resistant strains, due to their high mutation rate, which makes it mandatory to continually search for, or develop, new antiviral compounds. This review describes natural and synthetic antivirals in chronological order, with an emphasis on natural compounds, even when their mechanisms of action are not completely understood, that could serve as the basis for future development of novel and/or complementary antiviral treatments.

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“…The residue was washed with ethanol (10 mL) and ether (10 mL) to give compounds 5-8. General synthetic procedure for compounds [11][12][13][14][15][16][17][18][19][20][21][22][23] The solution of compound 1 (1 mmol) and corresponding acid (1.1 mmol) in CH 2 Cl 2 (30 mL) and ethanol (30 mL) was refluxed for 6 h under N 2 and then concentrated in vacuo. The residue was washed with ethanol (10 mL) to give compounds 11-23.…”

Section: 367-tetrahydroxyphenanthroquinolizidine (4)mentioning

confidence: 99%

“…An additional advantage is the natural products can be a candidate that possesses the desirable biological activities. and their analogs [e.g., 7-methoxycryptopleurine (1), Scheme 1] possess unique and interesting biological properties including vesicant (18), antimicrobial (22), antianimal-virus (23,24), and antitumor (25)(26)(27) activities. To date, most of the studies have been focused on antitumor activity in medicinal formulation.…”

mentioning

confidence: 99%

Design, Synthesis, Anti‐Tobacco Mosaic Virus (TMV) Activity, and SARs of 7‐Methoxycryptopleurine Derivatives

et al. 2014

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A series of 7-methoxycryptopleurine derivatives 2-23 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited excellent in vivo anti-TMV activity, of which 7-methoxycryptopleurine salt derivatives 16, 19, and 23 displayed significantly higher activity than 7-methoxycryptopleurine (1) and commercial ribavirin and ningnanmycin. Salification, the most commonly employed method for modifying physical-chemical properties, did significantly increase antiviral activity, and different salt forms displayed different antiviral effect. This study provides fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus.

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Cryptopleurine, an Active Antiviral Alkaloid from Boehmeria cylindrica (L.) Sw. (Urticaceae)

Cited by 36 publications

References 1 publication

Antimicrobially Active Alkaloids

Antimicrobially Active Alkaloids

Antivirals against animal viruses

Design, Synthesis, Anti‐Tobacco Mosaic Virus (TMV) Activity, and SARs of 7‐Methoxycryptopleurine Derivatives

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