Cryptosporidium in acquired immunodeficiency syndrome

Cohen, Jerome D.; Ruhlig, Lee; Jayich, Steven A.; Tong, Myron J.; Lechago, Juan; Snape, William J.

doi:10.1007/bf01312954

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…Identification of oocysts in stool samples has replaced intestinal biopsy as the preferred diagnostic technique (see "Diagnosis" section). Eosinophilia has been reported by some (25,107,147,195,217,241), and abnormal tests of malabsorption have been reported by others (12,26,62,95,171,180,216,241,244,249,291,292,294). Radiographic findings have been nonspecific, including prominent mucosal folds, air-fluid levels, distended loops of intestine, and disordered motility (28,39,43,195).…”

Section: Infection In Humansmentioning

confidence: 99%

“…associated with the pulmonary tree, although not as clearly attached to cells as in the intestinal tract. Histologic changes in the intestinal tract include blunting and loss of villi, lengthening of crypts, infiltration of the lamina propria with lymphocytes, polymorphonuclear leukocytes, and plasma cells (12,62,175,292).…”

Section: Infection In Humansmentioning

confidence: 99%

“…Concurrent human infections with Cryptosporidium sp. and other enteric pathogens (from case reports) 178,199,216,218,244,268,281,291,292 Bacteriab 10 54 19 10, 12, 31,35,41,43,46,49,60,62,63,144,145,147,149,155,164,166,173,175,178,195,199,216,217,224,244,245,249,251,268,281,283,291,292,299 Fungic 32 33 97 12, 31, 35,41,46,…”

Section: Infection In Humansmentioning

confidence: 99%

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Cryptosporidium Spp. And Cryptosporidiosis

Fayer¹,

Ungar²

1987

The Pediatric Infectious Disease Journal

106

163

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Anser anser (domestic goose) C. baileyi Current, Upton and Haynes, Gallus gallus (domestic chicken) C. bovis Barker and Carbonell, 1974 Bos taurus (ox) C. crotali Triffit, 1925 Crotalus confluens (snake) C. ctenosauris Duszynski, 1969 Costa Rican lizard C. cuniculus Inman and Takeuchi, 1979 Oryctolagus cuniculus (domestic rabbit) C. felis Iseki, 1979 Felis catis (domestic cat) C. garnhami Bird, 1981 Homo sapiens (man) C. lampropeltis Anderson, Dusynski, Marquardt, 1968 Lampropeltis calligaster (lizard) C. meleagridis Slavin, 1955 Meleagris gallopavo (turkey) C. muris Tyzzer, 1907 Mus musculus (domestic mouse)

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Section: Infection In Humansmentioning

confidence: 99%

Section: Infection In Humansmentioning

confidence: 99%

See 1 more Smart Citation

Cryptosporidium Spp. And Cryptosporidiosis

Fayer¹,

Ungar²

1987

The Pediatric Infectious Disease Journal

106

163

View full text Add to dashboard Cite

show abstract

Section: Infection In Humansmentioning

confidence: 99%

Section: Infection In Humansmentioning

confidence: 99%

Cryptosporidium spp. and cryptosporidiosis.

Fayer¹,

Ungar²

1986

Microbiological Reviews

351

160

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Anser anser (domestic goose) C. baileyi Current, Upton and Haynes, 1986 Gallus gallus (domestic chicken) C. bovis Barker and Carbonell, 1974 Bos taurus (ox) C. crotali Triffit, 1925 Crotalus confluens (snake) C. ctenosauris Duszynski, 1969 Costa Rican lizard C. cuniculus Inman and Takeuchi, 1979 Oryctolagus cuniculus (domestic rabbit) C. felis Iseki, 1979 Felis catis (domestic cat) C. garnhami Bird, 1981 Homo sapiens (man) C. lampropeltis Anderson, Dusynski, Marquardt, 1968 Lampropeltis calligaster (lizard) C. meleagridis Slavin, 1955 Meleagris gallopavo (turkey) C. muris Tyzzer, 1907 Mus musculus (domestic mouse)

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Pilot study of Sandostatin (octreotide) therapy of refractory HIV-associated diarrhea

et al. 1991

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Seventeen AIDS patients were enrolled in a prospective open-label dose-finding study of octreotide (Sandostatin) therapy for refractory diarrhea. Five were nonevaluable due to progression of AIDS symptomatology, and one was excluded because of lack of confirmation of HIV infection. Five of 11 evaluable patients responded to therapy (45%); two each at 50 micrograms and 100 micrograms, and one at 250 micrograms thrice daily doses. A sixth patient demonstrated a moderate reduction in stool volume at 250 micrograms thrice daily, which, although deemed clinically relevant, did not meet the criteria for response. On discontinuation of therapy, diarrhea recurred in all patients within 1-12 days, and responded to reinitiation of octreotide in those five patients who resumed treatment. Only one of the three patients with concurrent cryptosporidial infection responded to treatment. The drug was well tolerated, with mild symptomatology in three patients. Long-term treatment at a stable dose was effective in three of five treated patients for periods for seven months in one (moderate responder) and one year in two. One patient required dose increases to control symptoms, but after one year of treatment developed severe nausea following injections, which required dose cessation. One patient had partial control of his diarrhea for only three months despite two dose increases. These data suggest that octreotide may be of useful therapeutic value in HIV-associated diarrhea and that further studies are indicated.

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Cryptosporidium in acquired immunodeficiency syndrome

Cited by 13 publications

References 24 publications

Cryptosporidium Spp. And Cryptosporidiosis

Cryptosporidium Spp. And Cryptosporidiosis

Cryptosporidium spp. and cryptosporidiosis.

Pilot study of Sandostatin (octreotide) therapy of refractory HIV-associated diarrhea

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