Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling

Rahman, Naimur; Jeon, Miso; Song, Ho‐Yeon; Kim, Yong Sik

doi:10.1016/j.phymed.2015.12.004

Cited by 42 publications

(27 citation statements)

References 35 publications

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“…Cryptotanshinone inhibits phosphorylation of STAT3 during early adipogenesis and then downregulates the expression of the early transcription factors C/EBP β and PPAR γ to suppress preadipocyte differentiation [99]. Sal B can also suppress the expression of PPAR γ and C/EBP α and increase the expression of GATA binding proteins 2 and 3 to prevent the differentiation of preadipocytes and weight gain in obese mice [100].…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Chang

et al. 2016

Oxidative Medicine and Cellular Longevity

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Aging-associated cardiovascular diseases (CVDs) have some risk factors that are closely related to oxidative stress. Salvia miltiorrhiza (SM) has been used commonly to treat CVDs for hundreds of years in the Chinese community. We aimed to explore the effects of SM on oxidative stress in aging-associated CVDs. Through literature searches using Medicine, PubMed, EMBASE, Cochrane library, CINAHL, and Scopus databases, we found that SM not only possesses antioxidant, antiapoptotic, and anti-inflammatory effects but also exerts angiogenic and cardioprotective activities. SM may reduce the production of reactive oxygen species by inhibiting oxidases, reducing the production of superoxide, inhibiting the oxidative modification of low-density lipoproteins, and ameliorating mitochondrial oxidative stress. SM also increases the activities of catalase, manganese superoxide dismutase, glutathione peroxidase, and coupled endothelial nitric oxide synthase. In addition, SM reduces the impact of ischemia/reperfusion injury, prevents cardiac fibrosis after myocardial infarction, preserves cardiac function in coronary disease, maintains the integrity of the blood-brain barrier, and promotes self-renewal and proliferation of neural stem/progenitor cells in stroke. However, future clinical well-designed and randomized control trials will be necessary to confirm the efficacy of SM in aging-associated CVDs.

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Section: Resultsmentioning

confidence: 99%

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Chang

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Of note is that the traditional Chinese herbals provide a non-negligible candidate pool for digging of new STAT3 inhibitors. Diverse in structure, these natural products brought new understanding in the biological functional mechanism with STAT3 and novel starting points with considerable improving space 31–35 . Attempts in the characterization and optimization for these NP as STAT3 inhibitors may yield admirable outputs.…”

Section: Discussionmentioning

confidence: 99%

Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain

Qiu

Zhu

Luo

et al. 2017

Sci Rep

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Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic target. Current research showed that a natural product, shikonin, along with its synthetic analogues, is able to inhibit the activity of STAT3 potently. The potential space of shikonin in developing novel anti-cancer agents encouraged us to carry out the investigation of the probable binding mode with STAT3. From this foundation, we have designed new types of STAT3 SH2 inhibitors. Combined simulations were performed to filter for the lead compound, which was then substituted, synthesized and evaluated by a variety of bioassays. Among the entities, PMM-172 exhibited the best anti-proliferative activity against MDA-MB-231 cells with IC50 value 1.98 ± 0.49 μM. Besides, it was identified to decrease luciferase activity, induce cell apoptosis and reduce mitochondrial transmembrane potential in MDA-MB-231 cells. Also, PMM-172 inhibited constitutive/inducible STAT3 activation without affecting STAT1 and STAT5 in MDA-MB-231 cells, and had no effect in non-tumorigenic MCF-10A cells. Moreover, PMM-172 suppressed STAT3 nuclear localization and STAT3 downstream target genes expression. Overall, these results indicate that the antitumor activity of PMM-172 is at least partially due to inhibition of STAT3 in breast cancer cells.

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“…3T3-L1 mouse embryonic fibroblasts (Korean Cell Line Bank, KCLB-10092.1) were propagated and induced to differentiate with DMEM containing 10% FBS and MDI (0.5 mM IBMX, 1 mM dexamethasone, and 10 mg/ml insulin: used for adipogenic hormonal stimulation) as previously described [15]. Before addition to the medium, MG was completely dissolved in DMSO (SigmaeAldrich), and the stock solution was stored at À20 C until use.…”

Section: Cell Culture Differentiation and Treatmentmentioning

confidence: 99%

“…This procedure was performed as described elsewhere [15]. Stained cells were photographed using an Axiovert-25 microscope (Carl Zeiss, Jena, Germany).…”

Section: Oil Red O Stainingmentioning

confidence: 99%

See 1 more Smart Citation

Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis

Jeon

Rahman

Kim

2016

Biochemical and Biophysical Research Communications

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Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling

Cited by 42 publications

References 35 publications

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain

Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis

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