Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis

Song, Hongjia; Jiang, Lu-jing; Yang, Wanchun; Dai, Yuchao; Wang, Yao; Li, Zhuoming; Lu, Jing; Chen, Jianwen

doi:10.1016/j.biopha.2023.115105

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…It is a significant cause of irreversible airway stenosis and airflow limitation. In recent years, molecular mechanisms and clinical research on airway remodeling have developed rapidly, but the prevalence, disability rate and mortality of diseases with airway remodeling as the primary manifestation, such as asthma and chronic obstructive pulmonary disease, remain high [ 34 , 35 ]. Through bibliometric analysis by CiteSpace and Vosviewer, the research progress of airway remodeling can be understood to more accurately predict the future research direction [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Research trends on airway remodeling: A bibliometrics analysis

Liu,

Wang,

Chen

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Research trends on airway remodeling: A bibliometrics analysis

Liu,

Wang,

Chen

et al. 2024

Heliyon

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“…Chronic obstructive pulmonary disease (COPD), abbreviated as COPD, is a common respiratory system disease [1] and a widely prevalent disease [2]. Patients with chronic obstructive pulmonary disease not only have respiratory symptoms, but also involve the cardiovascular system [3], may also experience venous thromboembolism [4], and may also develop anxiety and depression.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of the “General Practitioner-Specialist” Combination in the Community Management of Chronic Obstructive Pulmonary Disease

2024

FMSR

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The research objective of this article is to explore the effectiveness evaluation of the combination of general and specialized departments in the management of chronic obstructive pulmonary disease (COPD) in the community. The research method of this article is as follows:80 patients with COPD in stable stage who signed a family doctor from July to December, 2022 were randomly divided into general management group (control group) and full-time management group (observation group). The general management group implemented the routine chronic disease management mode of general medical follow-up. The full-time management group implements the joint management of chronic obstructive pulmonary disease by general practitioners and specialties. Six months after the implementation of different management modes, the lung function index, dyspnea degree and symptom score, anxiety and depression score, the number of acute attacks and patient satisfaction were compared between the two groups. After 6 months of intervention, there were no lost cases in both groups. The improvement of lung function, dyspnea degree and symptom score, anxiety and depression score and patient satisfaction in the observation group were better than those in the control group, and there was no significant difference in the number of acute attacks between the two groups. The combination of full-time and full-time management of COPD is effective and can be further promoted.

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“…5,6 In recent years, proprietary Chinese medicines have become essential players in the clinical treatment of diseases. For example, studies have shown that cryptotanshinone 7 and scutellarein 8 can alleviate chronic obstructive pulmonary disease, and sodium houttuynia 6 has a protective effect against chronic airway inflammation. Capsaicin (8-methyl-N-geranyl-6-nonamide, CAP) is a naturally occurring substance extracted from Capsicum annuum in the Solanaceae family, that has exerted multiple pharmacological effects and therapeutic effects on various diseases, including cancer, 9 diabetic cardiovascular disease 10 and pain.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin Attenuates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Autophagy Through Regulation of the TRPV1/AKT Pathway

Hu,

Liu,

Wang

et al. 2024

JIR

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Acute lung injury (ALI) is a severe pulmonary disease characterized by damage to the alveoli and pulmonary blood vessels, leading to severe impairment of lung function. Studies on the effect of capsaicin (8-methyl-N-geranyl-6-nonamide, CAP) on lipopolysaccharide (LPS)-induced ALI in bronchial epithelial cells transformed with Ad12-SV40 2B (BEAS-2B) are still limited. This study aimed to investigate the effect and specific mechanism by which CAP improves LPS-induced ALI. Methods: The present study investigated the effect of CAP and the potential underlying mechanisms in LPS-induced ALI in vitro and vivo via RNA sequencing, Western blotting (WB), quantitative real-time reverse transcription PCR (qRT-PCR), enzyme-linked immunosorbent assay (ELISA), and transmission electron microscopy (TEM). The TRPV1 inhibitor AMG9810 and the AKT agonist SC79 were used to confirm the protective effect of the TRPV1/AKT axis against ALI. The autophagy agonist rapamycin (Rapa) and the autophagy inhibitors 3-methyladenine (3-MA) and bafilomycin A1 (Baf-A1) were used to clarify the characteristics of LPSinduced autophagy. Results: Our findings demonstrated that CAP effectively suppressed inflammation and autophagy in LPS-induced ALI, both in vivo and in vitro. This mechanism involves regulation by the TRPV1/AKT signaling pathway. By activating TRPV1, CAP reduces the expression of P-AKT, thereby exerting its anti-inflammatory and inhibitory effects on pro-death autophagy. Furthermore, prior administration of CAP provided substantial protection to mice against ALI induced by LPS, reduced the lung wet/dry ratio, decreased proinflammatory cytokine expression, and downregulated LC3 expression. Conclusion: Taken together, our results indicate that CAP protects against LPS-induced ALI by inhibiting inflammatory responses and autophagic death through the TRPV1/AKT signaling pathway, presenting a novel strategy for ALI therapy.

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Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis

Cited by 11 publications

References 40 publications

Research trends on airway remodeling: A bibliometrics analysis

Research trends on airway remodeling: A bibliometrics analysis

Evaluation of the Effect of the “General Practitioner-Specialist” Combination in the Community Management of Chronic Obstructive Pulmonary Disease

Capsaicin Attenuates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Autophagy Through Regulation of the TRPV1/AKT Pathway

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