Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity

Wang, Jiye; Zhang, Guangji; Dai, Chen; Gao, Xiufei; Wu, Jianbin; Shen, Li; Chen, Zhe; Liu, Pei

doi:10.1177/0300060516685513

Cited by 30 publications

(15 citation statements)

References 47 publications

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“…Firstly, the efficacy of the investigated compound is relatively low as reflected by the proliferation assay. Nevertheless, based on our data and one publication 62 , the inhibition potency of ICTS was stronger than cryptotanshinone in SGC-7901 and MKN-45 cells. Different inhibitory effects of ICTS on different gastric cancer cells could be due to their discrepant differentiation potentials and cell types, which would be explained by further related studies.…”

Section: Discussionsupporting

confidence: 61%

Inhibitory effects of isocryptotanshinone on gastric cancer

Chen

Huang

et al. 2018

Sci Rep

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Gastric cancer (GC) is one of the most common digestive malignancies globally, and the prognosis of patients with advanced tumors remains poor. Isocryptotanshinone (ICTS), isolated from Salvia miltiorrhiza, was found to inhibit the proliferation of lung and breast cancer cells. However, whether ICTS has anticancer activities against GC is unknown. In the present study, we reported that the proliferation of GC cells was inhibited by ICTS in a dose- and time-dependent manner. After treatment with ICTS, GC cells were arrested in the G1/G0 phase of cell cycle and the apoptotic cells were induced in a dose-dependent manner. Additionally, ICTS suppressed the expression of cell cycle- and apoptosis-associated proteins (e.g., Cyclin D1, phosphorylated Rb, E2F1, Mcl-1, Bcl-2, and Survivin). ICTS inhibited the phosphorylation of STAT3 in a dose-dependent manner. Down-regulated STAT3 attenuated the expression of Cyclin D1, p-Rb, and Survivin, which remarkably increased the sensitivity of ICTS in GC cells; overexpression of STAT3 restored the cell growth and proliferation and the protein expression suppressed by ICTS. ICTS also suppressed the xenograft tumor growth in BALB/c nude mice. Together, these data indicate that ICTS inhibits GC proliferation by inducing G1/G0 cell cycle arrest and apoptosis via inhibiting the STAT3 signaling pathway.

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Section: Discussionsupporting

confidence: 61%

Inhibitory effects of isocryptotanshinone on gastric cancer

Chen

Huang

et al. 2018

Sci Rep

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“…Quercetin was reported to enhance the sensitivity of breast cancer cells to doxirubicin by downregulating p-Akt expression arising from increased expression of PTEN (18). Cryptotanshinone enhanced the anticancer activity of doxirubicin in gastric cancer (GC) cells via STAT3 inactivation and suppression of STAT3-regulated antiapoptotic gene expression (19). Taken together, these agents serve as adriamycin sensitizers.…”

Section: Discussionmentioning

confidence: 99%

Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway

Tang

Wang

et al. 2018

Oncol Rep

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Gastric cancer (GC) is one of the most common malignancies of the digestive tract. Adriamycin (ADR) has been widely utilized in various chemotherapy regimens for treating GC, yet its long-term application may increase drug resistance resulting in treatment failure. Increasing evidence shows that bioactive natural products can be used as chemotherapeutic sensitizers that can significantly improve chemotherapy sensitivity. Peiminine (PMI) is a biologically active component extracted from Fritillaria walujewii Regel. Thus, in the present study, we aimed to investigate whether peiminine (PMI) alters the chemosensitivity of GC to adriamycin (ADR). GC cells were treated with ADR with or without PMI. MTT assay, flow cytometry and a nude mouse tumor xenograft model of SGC7901 cells were used to evaluate the chemosensitization activity of PMI combined with ADR. Western blotting was used to examine the expression of cyclin D1 and cleaved PARP. The RayBio® Human RTK phosphorylation antibody array kit was used to test the differential protein expression. Compared with the ADR group, PMI combined with ADR significantly suppressed cell proliferation and induced cell apoptosis in vitro. The growth curve and tumor weight of the tumor xenografts were significantly decreased in mice treated with the combination of PMI and ADR. However, the organs showed no obvious abnormality after treatment with PMI plus ADR. The expression of cyclin D1 was decreased and the level of cleaved PARP was increased after treatment with PMI and ADR. The expression of p-EGFR and p-FAK was downregulated in cells treated with PMI and ADR, and the validation of p-EGFR and p-FAK was in accordance with the result of the phosphorylation antibody array kit. PMI may serve as a new chemosensitizer by inhibiting the proliferation and inducing the apoptosis to enhance the chemotherapeutic drug sensitivity of ADR in GC.

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“…Cryptotanshinone (CTT) is extracted from the root of Salvia miltiorrhiza Bunge (Danshen) and has numerous pharmacological effects, including antioxidant, anti-hyperlipidaemia, anti-inflammation and anti-diabetes effects [14,15]. Moreover, numerous studies have shown that CTT exhibits activities against a variety of human cancers in vitro and in vivo and can be used for the management of human leukaemia, colorectal cancer, pancreatic cancer, breast cancer, prostate cancer, liver cancer, and gastric carcinoma [16][17][18]. However, the potential effect of CTT on bladder cancer and its mechanism remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway

Liu¹,

Lin²,

Chen³

et al. 2020

J. Cancer

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Cryptotanshinone (CTT), extracted from the root of Salvia miltiorrhiza Bunge (Danshen), exhibits activities against a variety of human cancers in vitro and in vivo. The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN.

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Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity

Cited by 30 publications

References 47 publications

Inhibitory effects of isocryptotanshinone on gastric cancer

Inhibitory effects of isocryptotanshinone on gastric cancer

Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway

Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway

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