Crystal and molecular structure of a mercury-thiosteroid complex

Terzis, Aris; Faught, J. Brian; Pouskoulelis, G.

doi:10.1021/ic50206a055

Cited by 9 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thiols combine with a mercury halide to form complicated clusters or polymeric structures containing Hg-S and in some cases Hg-X interactions [5][6][7][8]15,23,28]. Homoleptic thiolates of mercury(II) can be mononuclear (Hg(SR) 2 , Hg(SR) 3 , Hg(SR) 4 [33][34][35]. As an attempt to explore further the chemistry of mercury-thiolates, the present study describes the synthesis of mercury complexes with thiolates and their characterization by IR and NMR ( 1 H and 13 C) spectroscopic methods.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

et al. 2009

View full text Add to dashboard Cite

Abstract. Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl 2 ]− and [Hg(RS) 2 ] have been prepared and characterized by IR and NMR ( 1 H and 13 C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S-H vibrations in IR and significant downfield shifts in the C-S resonance in 13 C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold, P. citrinum.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In contrast, simple thiols combine with HgX 2 (X = halide) to form complicated clusters or polymeric structures containing Hg−S and, in some cases, Hg−X interactions . Homoleptic thiolates of mercury(II) can be mononuclear (Hg(SR) 2 , Hg(SR) 3 , Hg(SR) 4 ), dinuclear (Hg 2 (SR) 3 , Hg 2 (SR) 6 ), trinuclear (Hg 3 (SR) 4 ), tetranuclear (Hg 4 (SR) 6 ), pentanuclear (Hg 5 (SR) 8 ), or polynuclear ([Hg(SR) n ] ∞ ) (and with variable charge depending on the R group). ,− In contrast, mercury(II) compounds containing both monodentate thiolate and halide are polymeric and either one-dimensional ([Hg(SR)Cl 2 ] ∞ and [Hg(S−steroid)Br] ∞ ) or two-dimensional ([Hg(SMe)X] ∞ (X = Cl or Br) and [Hg(SPr i )Cl] ∞ ). − Molecular compounds with both thiolate and halide are rare but can be tetranuclear {(Ph 4 P)[(μ-SEt) 5 (μ-Br)(HgBr) 4 ], (Bu n 4 N) 2 [Hg 4 (SR) 6 X 4 ) (R = SEt, SPr i )} and heptanuclear [Hg 7 (SC 6 H 11 ) 12 X 2 ], where X = Cl, Br, or I. , …”

Section: Introductionmentioning

confidence: 99%

Structure-Directing Influence of Halide in Mercury Thiolate Clusters

et al. 2005

View full text Add to dashboard Cite

Under identical conditions, the reaction of 2-aminoethanethiol hydrochloride with HgX(2) (X = Cl and Br) in water yielded discrete hexanuclear [Hg(6)Cl(8)(SCH(2)CH(2)NH(3))(8))]Cl(4).4H(2)O (1) and nonanuclear [Hg(9)Br(15)(SCH(2)CH(2)NH(3))(9)](Cl(0.8)Br(0.2))(3) (2) complexes with unusual coordination environments. Compound 1 crystallizes as triclinic with a = 9.434(2) Angstroms, b = 10.999(2) Angstroms, c = 13.675(7) Angstroms, alpha = 92.9(7) degrees, beta = 105.2(7) degrees, and gamma = 96.9(7) degrees, whereas 2 is monoclinic with a = 14.162(3) Angstroms, b = 8.009(16) Angstroms, c = 19.604(4) Angstroms, alpha = gamma = 90.0 degrees, and beta = 92.7(3) degrees. In both cases, it is observed that the halide creates the secondary structure around trinuclear units (dimer in 1 and trimer in 2) through Hg-X bonding. Two independent types of Hg atoms (four- and five-coordinate in 1) and (three- and four-coordinate in 2) are observed. The geometry around Hg is quite variable with bridging thiolate and both bridging and terminal halides. The angles around Hg associated with the S atoms are more obtuse than expected from mercury(II) thiolates with a coordination number of more than 2. Intermolecular hydrogen bonding involving NH(3)(+), water molecules, and the halide atoms is responsible for the three-dimensional network in both compounds. Relatively short Hg...Hg interactions in 1 (3.797 and 3.776 Angstroms) and in 2 (3.605 and 3.750 Angstroms) are also observed. The compounds have been characterized with the help of (1)H and (13)C NMR, UV-Vis, infrared, Raman, and mass spectrometry, thermogravimetric analysis, and single X-ray crystallography.

show abstract