Crystal growth, structure and morphology of hydrocortisone methanol solvate

Structural, Thermodynamic, and Kinetic Aspectsof the Trimorphism of Hydrocortisone

“…In this context it must be mentioned that Petropavlov and coworkers report on investigations on a metastable form of hydrocortisone 17. However, the reported unit cell parameters are in agreement with those published for the methanol solvate of hydrocortisone 14, 15…”

“…Crystal structures were reported only for the solvates of hydrocortisone with pyridine,13 with methanol,14, 15 and of a solid solution of hydrocortisone with iodohydrocortisone 16. Interestingly the unit cell parameters reported for the crystal structure of the solid solution are similar to those of the metastable form III , whose structure is also reported here.…”

A molecular dynamics simulation of solvent effects on the crystal morphology of HMX

“…The determination of the basic crystal morphology, as well as the assessment of the solvent effects on the crystal morphology, becomes more and more important in modern industry. A great number of attempts have been made to investigate the solvent effects on the crystal morphology experimentally and theoretically (simulation) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. In this, the work of Lahav and Leiserowitz [1,2] is seminal in relating the mechanistic aspects associated with habit modification to the specificity of the intermolecular interactions between crystallographically ordered crystal habit surfaces and solvent/or impurity molecules.…”

Crystal modification of rifapentine using different solvents

“…The differences in morphology of crystals of the same compound have frequently been reported in literature [3,4]. Possible reasons are a change of the relative growth rates of the different crystal faces caused by solvent [5,6] and impurity interaction [7] or by a change in supersaturation [8]. An alternative explanation is polymorphism, in which the same compound shows a different crystal structure.…”