Crystal size and properties of superparamagnetic iron oxide (SPIO) particles

Sjøgren, Carl E.; Johansson, Christer; Nævestad, Anne; Sontum, Per Christian; Briley‐Saebo, Karen C.; Fahlvik, Anne K.

doi:10.1016/s0730-725x(96)00335-9

Cited by 131 publications

(82 citation statements)

References 21 publications

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“…Currently applied techniques are centrifugation, size exclusion chromatography, and field flow fractionation. [17][18][19] While the first two techniques separate particles on the basis of their density or size, the latter technique utilizes the magnetic properties of SPIONs for their efficient fractionation.…”

Section: Sizementioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

911

574

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Section: Sizementioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

911

574

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“…When there is no external magnetic field, they usually do not exhibit magnetic properties. However, once an external magnetic field is applied, the MNPs become magnetized, a phenomenon known as superparamagnetism [42].…”

Section: Magnetismmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

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“…For the preparation of water-soluble SPIONs, the coprecipation method often leads to SPIONs with poorly defined nanocrystalline size, stoichiochemistry, and magnetism, which in turn influence the quality of MR signals. 51 Alternatively, high-quality, near-monodisperse SPIONs can be prepared by thermal decomposition of iron organic precursors, such as Fe(acac) 3 , Fe(CO) 3 , and Fe(oleic acid) 3 , at high temperatures in the presence of surfactants (oleic acid and oleylamine). 52 ,53 However, these SPIONs cannot be biofunctionalized as they are coated with hydrophobic surfactants and are water-insoluble, and do not have suitable functional groups for bioconjugation.…”

Section: Mr Molecular Imaging Of Tumor Angiogenesis By Targeting Intementioning

confidence: 99%

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes

Liu¹,

Yang²,

Zhang³

2013

IJN

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Angiogenesis is an essential step for the growth and spread of malignant tumors. Accurate detection and quantification of tumor angiogenesis is important for early diagnosis of cancers as well as post therapy assessment of antiangiogenic drugs. The cell adhesion molecule integrin αvβ3 is a specific marker of angiogenesis, which is highly expressed on activated and proliferating endothelial cells, but generally not on quiescent endothelial cells. Therefore, in recent years, many different approaches have been developed for imaging αvβ3 expression, for the detection and characterization of tumor angiogenesis. The present review provides an overview of the current status of magnetic resonance molecular imaging of integrin αvβ3, including the new development of high sensitive contrast agents and strategies for improving the specificity of targeting probes and the biological effects of imaging probes on αvβ3 positive cells.

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Crystal size and properties of superparamagnetic iron oxide (SPIO) particles

Cited by 131 publications

References 21 publications

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Magnetic drug delivery systems

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes

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Crystal size and properties of superparamagnetic iron oxide (SPIO) particles

Cited by 131 publications

References 21 publications

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Magnetic drug delivery systems

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin &alpha;v&beta;3 with magnetic probes

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A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes