Crystal‐storing histiocytosis and Bing‐Neel‐like syndrome revealing a small B‐cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma

Lequain, Hippolyte; Gerfaud‐Valentin, Mathieu; Fontaine, Juliette; Ferrant, Emmanuelle; Grumet, Pierre; Jamilloux, Yvan; Traverse-Gléhen, Alexandra; Sève, P.

doi:10.1002/ccr3.5202

Clinical Case Reports

2021

DOI: 10.1002/ccr3.5202

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Crystal‐storing histiocytosis and Bing‐Neel‐like syndrome revealing a small B‐cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma

Hippolyte Lequain

Mathieu Gerfaud‐Valentin

Juliette Fontaine

et al.

Abstract: Crystal-storing histiocytosis and Bing-Neel syndrome are two diseases induced by paraproteins. Herein, we report a rare case of crystal-storing histiocytosis associated with Bing-Neel-like neurological manifestations in the context of a small B-cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma.

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Cited by 2 publications

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Central nervous system crystal‐storing histiocytosis: A case report and literature review

Nathoo,

Larson,

Guo

et al. 2024

Euro J of Neurology

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BackgroundCrystal‐storing histiocytosis (CSH) is a rare form of histiocytosis with intralysosomal accumulations of immunoglobulins or paraproteins that aggregate as crystals. Central nervous system (CNS) involvement of CSH is uncommon but should be considered in cases of persistent parenchymal enhancement on neuroimaging.MethodsWe describe one local case of CNS CSH and 10 additional cases identified by literature review.ResultsAmong 11 CSH patients, lesions involved either the dura (2/11) or brain parenchyma (9/11). Two cases had leptomeningeal enhancement. One case had spinal cord involvement. Two cases were associated with marginal zone lymphoma; one case was associated with an immunoglobulin A‐plasma cell dyscrasia. Eight of 11 cases had outcome data available: 7/8 cases had clinical and/or radiological improvement and 1/8 had radiological stability.ConclusionsCentral nervous system involvement of CSH is rare. Potential cases should be comprehensively evaluated for lymphoma or myeloma with positron emission tomography/computed tomography (CT) of the body or alternatively, CT of the chest, abdomen, pelvis and nuclear bone scan, bone marrow biopsy, serum protein electrophoresis, and cerebrospinal fluid protein electrophoresis. Treatment is targeted toward the underlying malignancy.

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Central nervous system crystal‐storing histiocytosis: A case report and literature review

Nathoo,

Larson,

Guo

et al. 2024

Euro J of Neurology

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Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

et al. 2023

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Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

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Crystal‐storing histiocytosis and Bing‐Neel‐like syndrome revealing a small B‐cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma

Cited by 2 publications

References 10 publications

Central nervous system crystal‐storing histiocytosis: A case report and literature review

Central nervous system crystal‐storing histiocytosis: A case report and literature review

Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

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