Crystal-Storing Histiocytosis with Plasma Cell Neoplasm in the Setting of Chronic Carbamazepine Exposure

Cho, Woo Cheal; Hafeez, Safina; Shen, Peter U.F.

doi:10.4132/jptm.2018.05.25

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Macrophages with intra- and extracellular crystals, identified as silica by x-ray diffraction, were seen in all lesions. Cho et al presented a case of CSH, associated with MM, as a possible result of prolonged treatment with carbamazepine, an antiepileptic drug, for the management of peripheral neuropathy [ 19 ]. Cases of plasma cell neoplasm have been reported with carbamazepine exposure, but the mentioned case report addresses the first possible related CSH [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cho et al presented a case of CSH, associated with MM, as a possible result of prolonged treatment with carbamazepine, an antiepileptic drug, for the management of peripheral neuropathy [ 19 ]. Cases of plasma cell neoplasm have been reported with carbamazepine exposure, but the mentioned case report addresses the first possible related CSH [ 19 ]. When serum protein electrophoresis is negative, and immunohistochemistry fails to stain the intracytoplasmic crystals, diagnostic challenges arise.…”

Section: Discussionmentioning

confidence: 99%

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Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Wiese-Hansen

Leh

Hemsing

et al. 2021

JCM

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Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. In this article, we present a case of a 75-year-old female with IgG kappa monoclonal gammopathy of undetermined significance (MGUS) and signs of a non-crystallized version of immunoglobulin-storing histiocytosis (IgSH) in a vertebra corpus. Furthermore, we performed a literature review based on all cases of storing histiocytosis identified by literature search between 1987 and 2020 and identified 140 cases in total. The median age at diagnosis was 60 years (range 18–91), with an equal sex distribution (51% men). The majority of the patients had an underlying neoplastic B-cell disorder, most often multiple myeloma (MM), MGUS, or lymphoplasmacytic lymphoma (LPL). The main affected organ systems or tissue sites were bone (n = 52), followed by head and neck (n = 31), kidney (n = 23), lung (n = 20), and gastrointestinal (GI)-tract (n = 18). IgG was the main immunoglobulin class involved, and most cases were associated with kappa light chain expression. We conclude that IgSH is a rare disease entity but should be considered with unusual findings in several organ systems associated with monoclonal gammopathy, especially with kappa light chain expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Wiese-Hansen

Leh

Hemsing

et al. 2021

JCM

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Carbamazepine

2019

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Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

et al. 2023

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Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

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Crystal-Storing Histiocytosis with Plasma Cell Neoplasm in the Setting of Chronic Carbamazepine Exposure

Cited by 3 publications

References 9 publications

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Carbamazepine

Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

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