Crystal structure analysis of 5‐amino‐7‐(pyrrolidin‐1‐yl)‐2,4,4‐trimethyl‐1,4‐dihydro‐1,6‐naphthyridine‐8‐carbonitrile

Selvanayagam, S.; Rajakannan, V.; Rao, Shashidhar N.; Raj, S. Shanmuga Sundara; Fun, Hoong Kun; Raghukumar, V.; Velmurugan, D.

doi:10.1002/crat.200310167

Cited by 3 publications

(3 citation statements)

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“…The ORTEP diagram of the derivative 3b (Fig. 2) shown to be 1,6-naphthyridine, which is exactly matching with the reported 49 1,6-naphthyridine compounds, prepared by reacting enone of acetone with malononitrile and pyrrolidine (Scheme 4). 50 The other spectroscopic data were also matching with each other.…”

Section: Chemistrysupporting

confidence: 82%

“…In the case of acetone 3b, the product obtained was crystallized out as crystalline rods in ethyl acetate, and found suitable for XRD measurement. The ORTEP diagram of the derivative 3b (Figure 2) shown to be 1, 6-naphthyridine, which is exactly matching with the reported 49 1, 6naphthyridine compounds, prepared by reacting enone of acetone with malononitrile and pyrrolidine (Scheme 4). 50 The other spectroscopic data were also matching with each other.…”

Section: Scheme 2 Synthesis Of 1 6-naphthyridinessupporting

confidence: 81%

“…47,48 They have also reported the synthesis of nicotinonitrile and pyridinenitrile derivatives by the reaction of aldehydes with malononitrile in the presence of pyrrolidine. 49 In this line, it was of immense interest to explore the reaction of ketones with malononitrile in the presence of pyrrolidine.…”

Section: Introductionmentioning

confidence: 99%

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Domino synthesis of functionalized 1,6-naphthyridines and their in vitro anti-inflammatory and anti-oxidant efficacies

et al. 2015

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Bioactive 1, 6-naphthyridines were constructed through a one pot multicomponent method by reacting different ketones with malononitrile and pyrrolidine. In vitro anti-inflammatory and 1,1-diphenyl-2picrylhydrazyl (DPPH) scavenging activities for all the synthesized 1, 6-naphthyridines were further carried out. These results clearly show that compound 3e exhibited excellent anti-inflammatory activity with a percentage inhibition of 81.24±4.46 by membrane stabilization method and 77.85±0.46 by the albumin denaturation method at a concentration of 100 µg ml -1 , which is comparable to the standard Diclofenac. A noticeable DPPH scavenging activity of 82.08±1.81 % was also observed for the synthesized compounds when compared with the standard, Ascorbic acid..

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Section: Chemistrysupporting

confidence: 82%

Section: Scheme 2 Synthesis Of 1 6-naphthyridinessupporting

confidence: 81%