Crystal structure of 3-amino-9-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C₂₁H₁₆N₂O₂

Abstract

C 21 H 16 N 2 O 2 , monoclinic, P21/n (no. 14), a = 13.4768 (7)

Crystal structure of 3-amino-8-methoxy-1-(4-methoxy phenyl)-1H-benzo[f]chromene-2-carbonitrile, C22H18N2O3

“…Literature reveals that chromenes and benzochromenes are an important chemical synthon, associated with a broad range of pharmacological activities such as antimicrobial [2][3][4][5], anticancer agent [6] hypolipidemic [7], antioxidant [8,9], analgesic [10], antileishmanial [11,12], vascular-disrupting activity [13], estrogenic anticoagulant and antispasmolytic [14], blood platelet antiaggregating [15] effects and activities. As part of our programmed aim to develop new methodologies for the preparation of 1H-benzo[f ]chromene derivatives [16][17][18], we have synthesized the title compound under microwave irradiation conditions. In the title compound, the asymmetric unit of the title compound contains one independent molecule.…”