Crystal structure of (4-hydroxypiperidin-1-yl)(4-methylphenyl)methanone

The title compound, C13H16ClNO, contains a methylpiperidine ring in the stable chair conformation. The mean plane of the twisted piperidine ring subtends a dihedral angle of 39.89 (7)° with that of the benzene ring. In the crystal, weak C—H...O interactions link the molecules along the a-axis direction to form infinite molecular chains. H...H interatomic interactions, C—H...O intermolecular interactions and weak dispersive forces stabilize molecular packing and form a supramolecular network, as established by Hirshfeld surface analysis.

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(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

Gomathi¹,

Jonathan²,

Sumaya

et al. 2017

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In the title molecule, C 13 H 17 NO 2 , the piperidine ring assumes a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 45.49 (1) . In the crystal, molecules are linked by O-HÁ Á ÁO intermolecular hydrogen bonds, leading to a molecular chain running along the c-axis direction. The atoms of the hydroxy piperidine ring and the methyl group of methylphenyl ring are disordered over two sets of sites with refined occupancies of 0.754 (5) and 0.246 (5). Structure descriptionPiperidine and its derivative have played vital roles in the design of pharmaceutical drugs (Das & Brahmachari, 2013). It has been shown that the antioxidant activity of the title molecule can be enhanced by the substitution of hydroxyl, methoxy, nitro and alkyl groups on the piperidine ring system (Ravindernath & Reddy, 2017).In the compound (Fig. 1)

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Crystal structure of (4-hydroxypiperidin-1-yl)(4-methylphenyl)methanone

Cited by 3 publications

References 9 publications

Synthesis, structure elucidation, spectroscopic analysis, thermal and NLO properties of A new piperidine derivative – (4-Methylphenyl) (4-methylpiperidin-1-yl) methanone

Synthesis, structure elucidation, spectroscopic analysis, thermal and NLO properties of A new piperidine derivative – (4-Methylphenyl) (4-methylpiperidin-1-yl) methanone

Crystal structure of (4-chlorophenyl)(4-methylpiperidin-1-yl)methanone

(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

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