Crystal structure of a 1:1 complex between netropsin and d(CGCAATTGCG)₂

Abstract

CRYSTALLOGRAPHY OF BIOLOGICAL MACROMOLECULES the orphaned 3U-tem1inal end in the minor groove of the adjacent duplex where it synm1etrically pairs with the 5'-terminal guanine to form a d[G*(G.C)] base-tliplet. Our findings extend to the minor groove a DNA hydrogen bonding pattem which permits basepair recognition dming homologous recombination.