Crystal structure of a mammalian purple acid phosphatase 1 1Edited by R. Huber

Synthesis, molecular structure and spectroscopic, electrochemical and magnetic properties of a new dinuclear iron complex containing µ-sulfate-di-µ-alkoxo bridges: evaluating the influence of the sulfate bridge on the physicochemical properties of the di-µ-alkoxo-diiron unit

“…9 Mössbauer spectra of ufPAP 10 and bsPAP 11 have shown that the iron centers are in distinct coordination environments. This has been confirmed by X-ray crystallographic studies on TRAP, 12 rat bone, 13 and ufPAP. 14 Magnetic susceptibility studies have indicated an antiferromagnetic coupling constant J = -13 cm -1 at pH = 5.6 for the reduced form and J = -9 cm -1 at pH 5.1 for the oxidized form of bsPAP.…”

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

“…We have determined the crystal structure of pig purple acid phosphatase [23] and other groups have solved the structures of the rat enzyme [42,43]. The overall structural features of these mammalian enzymes are very similar, as expected based on the very high degree of sequence identity (>85%) [1].…”

Structure, function, and regulation of tartrate-resistant acid phosphatase

“…Coincident solution of the structure of recombinant rat TRAP at 2.3 Å resolution by another group of investigators confirmed the overall conclusions from the porcine structure. 119 The combination of structural and mechanistic studies provides insight into the catalytic mechanism of PAPs. In the initial step, the phosphate group of the substrate is coordinated to the divalent metal ion.…”