Crystal Structure of an Anti-Neoplastic Agent, O-Toluidinecyanoborane, C8h11bn2

Abstract

Figure 1. Molecular structure (50% displacement ellipsoids) of CSHMBNI. The selected bond distances and angles are: B- CommentWe have previously reported the synthesis and cytotoxic activity of amine-borane adducts of aliphatic heterocyclic amines in murine and human tumor cells [1][2][3][4]. The cyano-, carboxy-, carbomethoxy-, and the carbamoylborane adducts of piperidines, piperazines, morpholines and imidazoles were shown to be potent cytotoxic agents in L-1210, Tmolt 3 , and HeLa-S' suspended cells [5]. The cyano-and carboxyborane adducts of cyclohexylamines and toluidines were also shown to be cytotoxic towards suspended single cell tumors [6]. Several of these compounds were active at 8mg/Kg/day I. P. in the Ehrlich ascites carcinoma screen in-vivo.The

α‐Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: α‐chymotrypsin and trypsin

“…The N1-C2 [1.1514(18)Å], C2-B3 [1.5897 (19)Å] and B3-N4 [1.6129 (16)Å] distances in the BH 2 CN group of 1 are in accord with those found in other cyanoboranes. 21 The coordination geometry of the two boron atoms present in 1 is different. The boron atom with four substituents has a tetrahedral geometry, while the boron atom coordinated to two oxygen atoms and one carbon atom has a trigonal planar geometry.…”