“…Several works reported on the preparation of pyrimidopyrimidines and their derivatives have demonstrated their antiallergic [11,18,24], anti-cancer [12,21,[25][26][27][28], antihypertensive [15,29], anti-inflammatory utility and other antibiotic, antifungal and antibacterial properties [9][10][11][12][30][31][32][33][34]. Some pyrimidopyrimidines have fungicidal activities whereas others have been reported to be agricultural compounds [35][36][37][38][39][40][41][42][43]. Pyrimidopyrimidines also have veterinary uses as antibiotics, antiparasites, antipyretics, analgesics, analgesics and anti-inflammatories [44][45][46].…”